SML0256

2OHOA

≥98% (HPLC)

• Sinonimo/i: (9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid, 2-Hydroxy Oleic Acid, Minerval
• Formula empirica (notazione di Hill): C₁₈H₃₄O₃
• Numero CAS: 56472-29-8
• Peso molecolare: 298.46
• Numero MDL: MFCD07778553
• Codice UNSPSC: 12352200
• ID PubChem: 329825264
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Condizioni di stoccaggio: protect from light
• Colore: white to tan
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
• InChI: 1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-; JBSOOFITVPOOSY-KTKRTIGZSA-N

Descrizione

Applicazioni

2OHOA has been used as:

• a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures[1]
• in biophysical studies to study its effects on artificial membranes[2]
• to study its interactions with major membrane lipid films[3]

Azioni biochim/fisiol

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.[3]

2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

2OHOA is an antitumor agent; sphingomyelin synthase activator.

Informazioni sulla sicurezza

• Pittogrammi: GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H318
• Consigli di prudenza: P280 - P305 + P351 + P338
• Classi di pericolo: Eye Dam. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable