SML0404
6,8-Bis(benzylthio)-octanoic acid
≥98% (HPLC)
Sinonimo/i:
6,8-Bis[(phenylmethyl)thio-octanoic acid, CPI-613
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70,00 €
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394,00 €
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Cambia visualizzazione
5 MG
70,00 €
25 MG
394,00 €
About This Item
Formula empirica (notazione di Hill):
C22H28O2S2
Numero CAS:
Peso molecolare:
388.59
Numero MDL:
Codice UNSPSC:
12352106
ID PubChem:
NACRES:
NA.77
70,00 €
Prezzo di listino100,00 €Risparmia il 30%Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
powder
Colore
white to beige
Solubilità
DMSO: 15 mg/mL (clear solution)
Temperatura di conservazione
2-8°C
Stringa SMILE
OC(=O)CCCCC(CCSCc1ccccc1)SCc2ccccc2
InChI
1S/C22H28O2S2/c23-22(24)14-8-7-13-21(26-18-20-11-5-2-6-12-20)15-16-25-17-19-9-3-1-4-10-19/h1-6,9-12,21H,7-8,13-18H2,(H,23,24)
ZYRLHJIMTROTBO-UHFFFAOYSA-N
Applicazioni
6,8-Bis(benzylthio)-octanoic acid has been used as pyruvate dehydrogenase (PDH) inhibitor:
- to study its effects on neurite outgrowth in primary mouse dorsal root ganglia cells[1]
- to induce α-smooth muscle actin (αSMA) and pro-collagen I expression and to assess PDH enzyme activity in whole-cell lysates[2]
- to validate basal respiration in tissue respirometry[3]
Azioni biochim/fisiol
6,8-Bis(benzylthio)-octanoic acid (CPI-613) is a lipoate analog. It acts as a mitochondrial disrupter by blocking the mitochondrial enzymes pyruvate dehydrogenase and α-ketoglutarate dehydrogenase.[4]
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator that prevents cancer cells from metabolizing glucose for energy. 6,8-Bis(benzylthio)-octanoic acid has been granted orphan drug status by the US FDA for pancreatic cancer.
6,8-Bis(benzylthio)-octanoic acid is an E1α pyruvate dehydrogenase (PDH) modulator.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Aquatic Acute 1 - Aquatic Chronic 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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