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S4250

Sigma-Aldrich

D-Serine

≥98% (TLC), suitable for ligand binding assays

Sinonimo/i:

β-Hydroxyalanine, (R)-2-Amino-3-hydroxypropionic acid, Ser

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5 G
57,10 €
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122,00 €

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Cambia visualizzazione
5 G
57,10 €
25 G
122,00 €

About This Item

Formula empirica (notazione di Hill):
C3H7NO3
Numero CAS:
Peso molecolare:
105.09
Beilstein:
1721403
Numero CE:
Numero MDL:
Codice UNSPSC:
12352209
ID PubChem:
NACRES:
NA.32

57,10 €


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Nome del prodotto

D-Serine, ≥98% (TLC)

Saggio

≥98% (TLC)

Stato

powder

tecniche

ligand binding assay: suitable

Colore

white to off-white

applicazioni

cell analysis

Stringa SMILE

N[C@H](CO)C(O)=O

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
MTCFGRXMJLQNBG-UWTATZPHSA-N

Informazioni sul gene

human ... GRIN1(2902)

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Descrizione generale

D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase.[1]
D-serine is an unusual amino acid expressed in the mammalian brain.[2]

Applicazioni

D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells.[3] It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.[4]
D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL).[5][6]

Azioni biochim/fisiol

D-serine is essential for the normal development of dendrites, neuroblast migration and may have therapeutic potential for treating schizophrenia and depression states.[7] The levels of D-serine is elevated in traumatic brain injury (TBI).[8]
D-serine is an agonist and glycine mimic which is active at the strychnine-insensitive glycine binding site associated with the N-methyl-D-aspartate (NMDA) receptor as well as the inhibitory post-synaptic glycine receptor. Along with glutamate, it has a role in various physiological processes including synaptic plasticity and receptor transmission. Dysregulation of D-serine signaling has been linked with neurodegenerative diseases and disorders.[2][9]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Certificati d'analisi (COA)

Lot/Batch Number

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D-Glutamic acid ≥99% (TLC)

Sigma-Aldrich

G1001

D-Glutamic acid

L-Serine certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

54763

L-Serine

DL-Serine for synthesis

Sigma-Aldrich

8.41235

DL-Serine

Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS
Beltran-Castillo S, et al.
Mediators of Inflammation, 2018 (2018)
D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration.
Wolosker H
FEBS Journal, 275(14), 3514-3526 (2008)
D-serine as a gliotransmitter and its roles in brain development and disease
Van Horn MR, et al.
Frontiers in Cellular Neuroscience, 7, 39-39 (2013)
Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury
Perez EJ, et al.
The Journal of Clinical Investigation, 127(8), 3114-3125 (2017)
Antinociceptive effect of intracerebroventricular administration of d-serine on formalin-induced pain
Ito M, et al.
Journal of Anesthesia, 28(2), 228-234 (2014)

Domande

1–9 di 9 domande  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  3. What is the reason your D-Serine is not suitable for human consumption? Do you know from where suitable for human consumption D-Serine can be sourced?

    1 risposta
    1. The products that we sell are for research use only, they should not be used in humans.

      Utile?

  4. What is the solubility of Product S4250, D-Serine?

    1 risposta
    1. This product is soluble in water at a concentration of 50mg/mL. It is also soluble in 1M hydrochloric acid.  It is not soluble in ethanol or ether.

      Utile?

  5. How does the storage temperature relate to shipping conditions?

    1 risposta
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

      Utile?

  6. Is Product S4250, D-Serine, suitable for human consumption?

    1 risposta
    1. This product is not suitable for human consumption.  This product is intended primarily for laboratory research purposes and should not be used for any other purposes, including but not limited to, in vitro diagnostic purposes, in foods, drugs, medical devices, or cosmetics for humans or animals, or for other commercial purposes.

      Utile?

  7. What is the melting point for S4250, D-Serine?

    1 risposta
    1. The melting point for this product is 228°C.

      Utile?

  8. Can D-Serine, Product No. S4250, be autoclaved?

    1 risposta
    1. Yes, solutions of this product can be autoclaved.

      Utile?

  9. What is the Department of Transportation shipping information for this product?

    1 risposta
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Utile?

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