R1656
RAF1 (EE) (306-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
CMD1NN, NS5, RAF proto-oncogene serine/threonine-protein kinase, cRaf
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10 μG
510,00 €
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Cambia visualizzazione
10 μG
510,00 €
About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
fermentation/recombinant
Livello qualitativo
Ricombinante
expressed in baculovirus infected Sf9 cells
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Stato
buffered aqueous glycerol solution
Attività specifica
5100-6900 nmol/min·mg
PM
~63 kDa
Produttore/marchio commerciale
Precision
tecniche
cell based assay: suitable
Solubilità
water: soluble
N° accesso ID proteina
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... RAF1(5894)
Descrizione generale
Research area: Cell Signaling
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Rapidly Accelerated Fibrosarcoma (RAF) belongs to receptor tyrosine kinase (RTK) family. RAF exists as three isoforms A, B and C-RAF or RAF-1. [1] RAF1 links Ras family members with mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade.[2] The RAF-1 gene is mapped to the human chromosome at 3p25.2.[3]
Azioni biochim/fisiol
Rapidly Accelerated Fibrosarcoma 1(RAF1), a member of MAP kinase kinase kinase (MAP3K) family plays a vital role in cell signaling by directly interacting with GTPases and functions downstream in their signaling pathway.[4] RaF1 is activated by Ras in the presence of growth-promoting signals, leading to the activation of mitogen-activated protein kinase kinase (MEK1/MEK2) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/ERK2) downstream. [5] The activated ERK proteins control gene expression related to cell division, apoptosis, cell differentiation, and cell migration.[4] The gene is mutated or upregulated in prostate and bladder cancer.[5] Also, mutations are associated with Noonan syndrome, which leads to various physical abnormalities like craniofacial dysmorphisms, ocular, and musculoskeletal irregularities, neurocognitive impairment, and cardiac malformations.[4]
Stato fisico
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
Wong S, et al.
EMBO Molecular Medicine, 15(5), e17078-e17078 (2023)
Benjamin R Nixon et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1), 1138-1150 (2018-08-15)
Raf1/c-Raf is a well-characterized serine/threonine-protein kinase that links Ras family members with the MAPK/ERK signaling cascade. We have identified a novel splice isoform of human Raf1 that causes protein truncation and loss of the C-terminal kinase domain (Raf1-tr). We found
Raf-1: a kinase currently without a cause but not lacking in effects.
P Li et al.
Cell, 64(3), 479-482 (1991-02-08)
U R Rapp et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(14), 4218-4222 (1983-07-01)
We have molecularly cloned a unique acutely transforming replication-defective mouse type C virus (3611-MSV) and characterized its acquired oncogene. The viral genome closely resembles Moloney (M) murine leukemia virus (MuLV), except for a substitution in M-MuLV in the middle of
Raf kinases: function, regulation and role in human cancer
Leicht DT, et al.
Biochimica et Biophysica Acta, 1773(8), 1196-1212 (2007)
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