I8657
Interferon α from rat
≥95%, recombinant, expressed in bacteria, lyophilized powder, suitable for cell culture
Sinonimo/i:
IFN-α
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1 VIAL
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About This Item
792,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
rat
Livello qualitativo
Ricombinante
expressed in bacteria
Saggio
≥95%
Stato
lyophilized powder
PM
~19 kDa
Confezionamento
pkg of 1 vial
Concentrazione
300,000-800,000,000 units/mL
tecniche
cell culture | mammalian: suitable
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
rat ... Ifna_mapped(24480)
Descrizione generale
Azioni biochim/fisiol
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
Interferon α play a key role in the inhibition of in vitro proliferation of hematopoietic progenitors.[2] It mediates the regulation of gene expression that is responsible for development and functionality of innate and adaptive immunity.[3] It has been used as myelosuppressive agent for myeloproliferative neoplasms (MPNs).[2]
Stato fisico
Lyophilized from a solution containing citric acid buffered saline (CBS pH 5.0) and 125 mM trehalose
Risultati analitici
The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV) in the presence of 2mM glutathione. The cytopathic effect of 50% is produced with ~1 unit/mL interferon. Since there is no international rat interferon α standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Agnieszka Rynda et al.
PloS one, 5(1), e8720-e8720 (2010-01-22)
Conventional methods to induce tolerance in humans have met with limited success. Hence, efforts to redirect tolerogen uptake using reovirus adhesin, protein sigma 1 (psigma1), may circumvent these shortcomings based upon the recent finding that when reovirus psigma1 is engineered
The interferon system of teleost fish
Robertsen B
Fish & Shellfish Immunology, 20(2), 172-191 (2006)
Type I interferons (?/?) in immunity and autoimmunity
Theofilopoulos AN, et al.
Fish & Shellfish Immunology, 23(11), 307-335 (2005)
Jie-Hyun Kim et al.
Yonsei medical journal, 47(6), 793-798 (2006-12-28)
Combination therapy with interferon alpha (IFN-alpha) and ribavirin for 24 or 48 weeks according to HCV genotype has improved the overall sustained virological response (SVR) rates to approximately 40%. The aim of this study was to investigate the long-term efficacy
Jin Zhao et al.
PloS one, 8(5), e64301-e64301 (2013-06-07)
The cytokine interleukin-28B (IL-28B) has potential antiviral properties and regulatory roles in adaptive cellular immunity. A genome-wide association study identified a single nucleotide polymorphism near the IL-28B gene that strongly predicts response to hepatitis C treatment with interferon and ribavirin.
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