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SRE0013

Sigma-Aldrich

Interferon Alpha 2A human

recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), lyophilized powder

Sinonimo/i:

Interferon α 2A human, INFα2A

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About This Item

Codice UNSPSC:
41106305
NACRES:
NA.26

Ricombinante

expressed in HEK 293 cells

Livello qualitativo

Saggio

≥98% (SDS-PAGE)

Forma fisica

lyophilized powder

Temperatura di conservazione

−20°C

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Descrizione generale

IFN-α-2a belongs to the type I interferon protein family. Interferon α 2A is one among the three variants of IFN-α2. Recombinant human IFN-α-2a is expressed in human 293 cells as a glycosylated monomer of 165 amino acids, with an average molecular weight of 20 kDa (monomer).

Applicazioni

Interferon α 2A human has been used as an inhibitor of hepatitis D virus (HDV).

Azioni biochim/fisiol

Interferon Alpha 2A human is produced by many cell types in response to viral infection. IFN-α-2A has antiproliferative and antitumor activities, as well as induction of apoptosis and inflammatory response
Interferon α 2A might be implicated in the regression of proliferative diabetic retinopathy. Telaprevir and pegylated interferon–α-2a (PEG-IFN–α-2a) serves as a potential therapeutic method for hepatitis C virus (HCV). IFN α 2A along with IFN α 2b and IFN α2c exhibits anti-proliferative effect.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Interferon alpha-2a for proliferative diabetic retinopathy after complete laser panretinal photocoagulation treatment.
Leibovitch I, et al.
Ophthalmic Surgery, Lasers & Imaging Retina, 35(1), 16-22 (2004)
Guillaume Beauclair et al.
Journal of virology, 94(22) (2020-09-04)
Yellow fever virus (YFV) is an RNA virus primarily targeting the liver. Severe YF cases are responsible for hemorrhagic fever, plausibly precipitated by excessive proinflammatory cytokine response. Pathogen recognition receptors (PRRs), such as the cytoplasmic retinoic acid inducible gene I
Telaprevir and pegylated interferon?alpha?2a inhibit wild?type and resistant genotype 1 hepatitis C virus replication in patients
Kieffer T L, et al.
Hepatology, 46(3), 631-639 (2007)
Telaprevir and pegylated interferon?alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients.
Tara L K, et al.
Hepatology (2007)
A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection.
Bettina B, et al.
Antiviral Research, 141, 116-123 (2017)

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