I4032
Interleukin-21 from mouse
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Sinonimo/i:
IL-21
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10 μG
672,00 €
672,00 €
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Cambia visualizzazione
10 μG
672,00 €
About This Item
672,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Prodotti consigliati
Origine biologica
mouse
Ricombinante
expressed in E. coli
Saggio
≥97% (SDS-PAGE)
Stato
lyophilized powder
Potenza
40-120 ng/mL ED50
PM
predicted mol wt ~14.4 kDa
Confezionamento
pkg of 10 μg
Condizioni di stoccaggio
avoid repeated freeze/thaw cycles
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Il21(60505)
Azioni biochim/fisiol
IL-21 (interleukin-21) belongs to the IL-2 cytokine family. It is secreted by CD4+ T, natural killer (NK) and Th17 cells. IL-21 associates with IL-21 receptor and participates in B-cell proliferation, differentiation as well as apoptosis. It also promotes the cytotoxic activity of CD8+ T cells and natural killer cells.IL-21 plays a crucial role in the differentiation of follicular helper T cells. It also exhibits antitumor activity.[1][2] It is also involved in the activation of JAK-STAT (Janus kinase - signal transducer and activator of transcription), PI3K (phosphatidylinositol 3-kinase) and MAPK (mitogen activated protein kinase) pathways.[3]
IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation.
IL-21 and its receptor have important roles in T and B cell proliferation and natural killer cell maturation. Human and mouse IL-21 share 57% amino acid identity.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.
Risultati analitici
The biological activity is measured by its ability to induce proliferation of human N1186 T cells.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5.
Ferenc A Scheeren et al.
PloS one, 6(4), e17189-e17189 (2011-04-29)
Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate. Memory B cells were immortalized by expressing an inducible active mutant of the transcription factor Signal Transducer and Activator of Transcription 5
Mark J Kwakkenbos et al.
Nature medicine, 16(1), 123-128 (2009-12-22)
The B cell lymphoma-6 (Bcl-6) and Bcl-xL proteins are expressed in germinal center B cells and enable them to endure the proliferative and mutagenic environment of the germinal center. By introducing these genes into peripheral blood memory B cells and
Chi-Keung Wan et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(30), 9394-9399 (2015-07-15)
IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of
Shruti Bhatt et al.
Blood, 126(13), 1555-1564 (2015-07-22)
Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma characterized by overexpression of cyclin D1 in 95% of patients. MCL patients experience frequent relapses resulting in median survival of 3 to 5 years, requiring more efficient therapeutic regimens.
S Lajoie et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 44(7), 976-985 (2014-05-09)
Interleukin-21 (IL-21) has been implicated in the development of Th2-mediated immune responses; however, the exact role it plays in allergic diseases is not well understood. To elucidate the contribution of IL-21 receptor signalling to Th2-dependent immune responses in the lung.
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