G8761

(±)-Gossypol from cotton seeds

≥95% (HPLC), powder, PAF antagonist/inhibitor

• Sinonimo/i: (±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
• Formula empirica (notazione di Hill): C₃₀H₃₀O₈
• Numero CAS: 303-45-7
• Peso molecolare: 518.55
• Numero MDL: MFCD00017352
• Codice UNSPSC: 12352200
• ID PubChem: 24895349
• NACRES: NA.77

Proprietà

• Nome del prodotto: (±)-Gossypol from cotton seeds, ≥95% (HPLC)
• Livello qualitativo: 200
• Saggio: ≥95% (HPLC)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C([H])C1=C(C(O)=C(C2=C(C)C=C(C(C(C)C)=C(O)C(O)=C3C([H])=O)C3=C2O)C(C)=C4)C4=C(C(C)C)C(O)=C1O
• InChI: 1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3; QBKSWRVVCFFDOT-UHFFFAOYSA-N
• Informazioni sul gene: human ... AKR1B1(231) , BAD(572) , BCL2(596) , LDHA(3939) , LDHB(3945) , MCL1(4170)

Descrizione

Descrizione generale

Gossypol is considered as an antifertility agent. It is present in cottonseed as a yellowish pigment. This reactive sesquiterpene aldehyde is present in the family Malvaceae and has a molecular mass of 518.54.[1]

Applicazioni

(±)-Gossypol from cotton seeds has been used:

• as a standard to quantify the gossypol content in the extracts of leaves and flower buds[2]
• to study its antifertility effects on spermatogenesis in NMRI mice[1]
• to analyse its impact on human spermatozoa[3]
• to incorporate into the artificial diet for larval rearing[4]

Azioni biochim/fisiol

Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B₄, seukotriene D4, and PAF-acether.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H360F
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges