H4914

Honokiol

≥98% (HPLC), powder

• Sinonimo/i: 5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100
• Formula empirica (notazione di Hill): C₁₈H₁₈O₂
• Numero CAS: 35354-74-6
• Peso molecolare: 266.33
• Numero MDL: MFCD00016674
• Codice UNSPSC: 12352200
• ID PubChem: 24724501
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Solubilità: DMSO: 36 mg/mL
• Spettro attività antibiotica: Gram-positive bacteria; neoplastics
• Modalità d’azione: DNA synthesis | interferes
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O
• InChI: 1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2; FVYXIJYOAGAUQK-UHFFFAOYSA-N

Descrizione

Descrizione generale

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

Applicazioni

Honokiol has been used:

• to study its effects on plasmid hSirt3^102-399 deacetylation activity
• as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
• to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
• for intracerebroventricular (ICV) cannulation

Azioni biochim/fisiol

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Caratteristiche e vantaggi

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H318,H411
• Consigli di prudenza: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Classi di pericolo: Aquatic Chronic 2 - Eye Dam. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves