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G8377

Sigma-Aldrich

Guanosine 5′-monophosphate disodium salt hydrate

from yeast, ≥99%

Sinonimo/i:

5′-GMP-Na2, 5′-Guanylic acid disodium salt hydrate

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500 MG
53,00 €
1 G
65,10 €
5 G
226,00 €
25 G
353,00 €
100 G
1.060,00 €

53,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
500 MG
53,00 €
1 G
65,10 €
5 G
226,00 €
25 G
353,00 €
100 G
1.060,00 €

About This Item

Formula empirica (notazione di Hill):
C10H12N5Na2O8P · xH2O
Numero CAS:
5550-12-9
Peso molecolare:
407.18 (anhydrous basis)
Beilstein:
3586801
Numero CE:
226-914-1
Numero MDL:
MFCD00151238
Codice UNSPSC:
41106305
ID PubChem:
24895338
NACRES:
NA.51

53,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.

Origine biologica

yeast

Livello qualitativo

200

Saggio

≥99%

Stato

powder

Solubilità

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

Temperatura di conservazione

room temp

Stringa SMILE

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1
MEKWJTZTMVQYSU-CYCLDIHTSA-L

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Applicazioni

Guanosine 5′-monophosphate is suitable for use in:
  • the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure[1]
  • the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes[2]
  • the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS[3]

Azioni biochim/fisiol

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000367733
0000295415
BCCL3682
BCCM6620
0000367733

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Marcelo Ganzella et al.
Purinergic signalling, 8(1), 49-58 (2011-09-02)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered
Robbin R Vernooij et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)
The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and
Roberto Farina Almeida et al.
Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)
The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the
Simone Molz et al.
Neurochemical research, 30(1), 83-89 (2005-03-11)
Guanosine-5'-monophosphate (GMP) was evaluated as a neuroprotective agent against the damage induced by glutamate in rat hippocampal slices submitted to glucose deprivation. In slices maintained under physiological conditions, glutamate (0.01 to 10 mM), Kainate, alpha-amino-3-hydroxi-5-methylisoxazole-propionic acid (AMPA), N-methyl-D-aspartate (NMDA), 1S,3R-aminocyclopentane-1,3-dicarboxylic
Simone Molz et al.
Brain research, 1231, 113-120 (2008-07-29)
Glutamate is the main excitatory neurotransmitter in the mammalian nervous system and is essential for its normal functions. However, overstimulation of glutamatergic system due to hyperactivation of NMDA receptors and/or impairment of glutamate reuptake system has been implicated in many
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Protocolli

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Domande

Recensioni

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