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G7509
GABase from Pseudomonas fluorescens
lyophilized powder, Protein ≥30 % by biuret
Sinonimo/i:
GABase Enzyme, GABase from Pseudomonas, Pseudomonas GABase
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10 UNITS
525,00 €
25 UNITS
1.150,00 €
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Cambia visualizzazione
10 UNITS
525,00 €
25 UNITS
1.150,00 €
About This Item
Prodotti consigliati
Origine biologica
Pseudomonas fluorescens
Livello qualitativo
Saggio
≥30 % (biuret)
Stato
lyophilized powder
Attività specifica
≥0.5 units/mg protein
Composizione
Protein, ≥30% biuret
tecniche
inhibition assay: suitable
Temperatura di conservazione
−20°C
Descrizione generale
Applicazioni
Azioni biochim/fisiol
GABase catalyzes the conversion of γ-aminobutyric acid (GABA) to succinic acid in the central nervous system. It is used to measure GABA levels in various biological samples. p-Hydroxybenzaldehyde (HBA) is known to be a potential inhibitor on GABase.[3]
Definizione di unità
One unit will convert 1.0 μmole of γ-aminobutyric acid (GABA) to succinic semialdehyde and then to succinate per min with a stoichiometric reduction of 1.0 μmole of NADP+ at pH 8.6 at 25 °C.
Stato fisico
Partially purified lyophilized powder containing buffer salts and stabilizer
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Certificati d'analisi (COA)
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Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purification have not been established. Thus, biochemical and drug
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Glutamate (GLU) and gamma-aminobutyric acid (GABA) are neurotransmitters (NTs) with an essential role in signal transmission in the brain. Brain disorders, such as epilepsy, Alzheimer's and Parkinson's diseases, and traumatic brain injury can be linked to imbalances in the GLU-GABA
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It is well established that the glutamate decarboxylase (GAD) system is central to the survival of Listeria monocytogenes at low pH, both in acidic foods and within the mammalian stomach. The accepted model proposes that under acidic conditions extracellular glutamate
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What is the Department of Transportation shipping information for this product?
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How do I solubilize Product No. G7509, GABase from Pseudomonas fluorescens?
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Sigma recommends to dissolve the product with 75 mM phosphate buffer, pH 7.2, containing 25% (v/v) glycerol to a concentration of 2-5 units per mL. Keep the solution in an ice bath while using and store solution frozen. This solution may be stored frozen and thawed several times with only slight loss of activity.
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Are there any literature references that cite use of the Product No. G7509, GABase from Pseudomonas fluorescens?
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The product is cited in the reference Sulaimana, Saba A.J., et al., J of Enz Inhib and Med Chem. 18(4), 297-301 (2003).
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What is the shelf life of the Product No.G7509, GABase from Pseudomonas fluorescens?
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Sigma recommends retesting the product 3 years after its release date. The retest date will appear on the lot specific Certificate of Analysis for the product.
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