G3046
GDF-15
Sinonimo/i:
Growth Differentiation Factor 15, MIC-1, Macrophage inhibitory cyotkine-1
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Scegli un formato
25 μG
726,00 €
Scegli un formato
Cambia visualizzazione
25 μG
726,00 €
About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in CHO cells
Saggio
>97% (visualized with silver stain, SDS-PAGE)
Stato
lyophilized powder
PM
dimer 13 kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag)
tecniche
cell culture | mammalian: suitable
Impurezze
endotoxin, tested
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... GDF15(9518)
Descrizione generale
Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.2 It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1. [1]
Applicazioni
Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.[2]
Azioni biochim/fisiol
Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.[1]
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.[1]
Stato fisico
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.
Risultati analitici
Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Renal failure and the histopathological features of myeloma kidney reversed by intensive chemotherapy and peritoneal dialysis.
P E Rose et al.
British medical journal (Clinical research ed.), 294(6569), 411-412 (1987-02-14)
K P Bland et al.
Quarterly journal of experimental physiology (Cambridge, England), 74(6), 813-824 (1989-11-01)
In order to examine whether an aspiration mechanism exists in the vomeronasal organ (VNO) of the domestic ram, experiments were conducted in chloralose-anaesthetized animals using acute electromanometry and electrophysiological techniques. Stimulation of the ipsilateral cervical sympathetic nerve activated a mechanism
Jennifer Lee et al.
PloS one, 10(6), e0131506-e0131506 (2015-06-27)
Although inactivating frameshift mutations in the Transforming growth factor beta receptor type 2 (TGFBR2) gene are considered as drivers of microsatellite unstable (MSI) colorectal tumorigenesis, consequential alterations of the downstream target proteome are not resolved completely. Applying a click-it chemistry
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
