F8927

Flupirtine maleate salt

≥98% (HPLC)

• Sinonimo/i: 2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid ethyl ester maleate salt
• Formula empirica (notazione di Hill): C₁₅H₁₇FN₄O₂ · C₄H₄O₄
• Numero CAS: 75507-68-5
• Peso molecolare: 420.39
• Numero MDL: MFCD00941415
• Codice UNSPSC: 12352200
• ID PubChem: 24278445
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: white
• Solubilità: DMSO: soluble >20 mg/mL; H₂O: insoluble
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OC(=O)\C=C/C(O)=O.CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N
• InChI: 1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1-; DPYIXBFZUMCMJM-BTJKTKAUSA-N

Descrizione

Azioni biochim/fisiol

Flupirtine is commercially available as maleate salt. It exists in two polymorphs : flupirtine maleate A and B. Flupirtine is useful in treating muscular spasm, muscle tension and muscle stiffness. It is known to be effective in relieving back pain. Along with cytoprotection, flupirtine also offers protection against neurodegenerative disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer′s disease, Parkinson′s disease, Huntington′s chorea and AID (acquired immunodeficiency) associated encephalopathy. Flupirtine is found to be a potential drug for eye-related problems like maculopathy including diabetic retinopathy, retinitis pigmentosa and glaucoma. It is also proved to be helpful in preventing cardiac associated disorders such as myocardial ischemia and infarction, cerebral ischemia and infarction. Hepatitis is also prevented by the use of flupirtine.[1]

Non-opioid analgesic; cytoprotective versus PrP fragment 106-126

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)