SML1504

Tegaserod maleate

≥98% (HPLC)

• Sinonimo/i: 2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
• Formula empirica (notazione di Hill): C₁₆H₂₃N₅O · C₄H₄O₄
• Numero CAS: 189188-57-6
• Peso molecolare: 417.46
• NACRES: NA.77
• PubChem Substance ID: 329825925
• UNSPSC Code: 12352200
• MDL number: MFCD09028009
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O
• InChI: 1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-
• InChI key: CPDDZSSEAVLMRY-FEQFWAPWSA-N
• Gene Information: human ... HTR4(3360)

Descrizione

Application

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

Biochem/physiol Actions

Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC₅₀ of 7 nM.

Tegaserod is a serotonin 5-HT4 agonist.

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable