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C2505

Sigma-Aldrich

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

Sinonimo/i:

11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, 4-Pregnene-11β,21-diol-3,20-dione, Kendall’s Compound B, Reichstein’s Substance H

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500 MG
110,00 €

110,00 €

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500 MG
110,00 €

About This Item

Formula empirica (notazione di Hill):
C21H30O4
Numero CAS:
50-22-6
Peso molecolare:
346.46
Beilstein:
2339601
Numero CE:
200-019-6
Numero MDL:
MFCD00037715
Codice UNSPSC:
51111800
ID PubChem:
24278302
NACRES:
NA.77

110,00 €

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Nome del prodotto

Corticosterone, ≥92%

Origine biologica

synthetic (organic)

Saggio

≥92%

Stato

powder

Punto di fusione

179-183 °C (lit.)

Solubilità

chloroform: 50 mg/mL, clear, colorless to faintly yellow

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Informazioni sul gene

human ... EBP(10682) , SERPINA6(866)
rat ... Ar(24208) , Nr3c1(24413)

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Applicazioni

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice[1]
  • as a stress inducing hormone in pregnant mice[2]
  • to test its effect on depression-related behaviors in mice[3]

Azioni biochim/fisiol

Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.
Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands.[4] However, it may also be synthesized in non-adrenal tissues including leydig cells of testes[4] and in murine thymus.[5] Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress.[6] It is produced by HPA activation in response to stress in myeloid cells.[7] Elevated levels of corticosterone is observed in Huntington′s disease (HD).[8]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000429933
0000429933
0000403951
0000396683
0000391934

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Aldosterone ≥95% (HPLC)

Sigma-Aldrich

A9477

Aldosterone

2-Methyl-1,2-di-3-pyridyl-1-propanone 96%

Sigma-Aldrich

856525

2-Methyl-1,2-di-3-pyridyl-1-propanone

11-Deoxycortisol solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-061

11-Deoxycortisol solution

Reichstein’s substance S ≥98%

Sigma-Aldrich

R0500

Reichstein′s substance S

Cortisone solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-130

Cortisone solution

Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression
Niraula A, et al.
The Journal of Neuroscience, 38(9), 2328-2340 (2018)
Prenatal stress alters presynaptic marker proteins in the hippocampus of rat pups
Afadlal S, et al.
Neuroscience Letters, 470(1), 24-27 (2010)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
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Domande

  1. Which reagents should be used to dissolve product C2505, and what are the recommended storage conditions after it has been dissolved?

    1 risposta

    1. C2505 is soluble in Chloroform at 50 mg/mL, and should be colorless to faintly yellow in appearance.

      Although we cannot provide any verified recommendations for temperature storage of solution, other literature sources suggest that the solution can remain at room temperature if the solution stays clear for 3 days. These sources suggest that it is soluble in ethanol at 50 mg/ml, and that following reconstitution, aliquot and freeze (-20°C), for stock solutions to be stable for up to 3 months (at -20°C). There are additional sources that recommend dissolving in acetone, methanol, ethanol (10 mM), chloroform, and DMSO (100 mM). It is insoluble in water.

      Utile?

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