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C2755

Cortisone

synthetic, ≥95%, powder

Sinonimo/i:

17α,21-Dihydroxy-4-pregnene-3,11,20-trione, 17α-Hydroxy-11-dehydrocorticosterone, 4-Pregnene-17α,21-diol-3,11,20-trione, Kendall’s Compound E, Reichstein’s Substance Fa

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Cambia visualizzazione
A voi/SKUDisponibilitàPrezzo
250 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
44,40 €
1 g
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
61,90 €
5 g
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
201,00 €

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C21H28O5
Numero CAS:
Peso molecolare:
360.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
200-162-4
MDL number:
Beilstein/REAXYS Number:
1356062
Assay:
≥95%
Form:
powder

44,40 €


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Nome del prodotto

Cortisone, ≥95%

biological source

synthetic

Quality Segment

sterility

non-sterile

assay

≥95%

form

powder

technique(s)

inhibition assay: suitable

mp

223-228 °C (dec.) (lit.)

solubility

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)CC(=O)[C@H]23

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChI key

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Gene Information

human ... SERPINA6(866)

Application

Cortisone has been used:
  • to validate a 1β-HSD1 (11β-hydroxysteroid dehydrogenase type 1) inhibitor[1]
  • to study the sensitivity of erythropoietic and granulopoietic progenitor cells to cortisone[2]
  • in the determination of rates of cortisol oxidation by 11βHSD[3]

Biochem/physiol Actions

Cortisone (11 dehydro 17 hydroxycortico-sterone) is an anti-inflammatory glucocorticoid that delays wound healing after surgeries. It postpones the healing process by affecting the appearance of inflammatory cells, ground substance, fibroblasts, collagen, regenerating capillaries, and epithelial migration.[4] Glucocorticoids have anti-inflammatory, anti-allergic and immunosuppressive properties and are extensively used in treatment and therapy.[5]
Cortisone is a glucocorticoid; a corticosterone analog that has approximately twice the anti-inflammatory potency as corticosterone but much lower Na2+ retention potency.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Questo articolo
C2505C3130P6254
Cortisone ≥95%

Sigma-Aldrich

C2755

Cortisone

Corticosterone ≥92%

Sigma-Aldrich

C2505

Corticosterone

Prednisone ≥98%

Sigma-Aldrich

P6254

Prednisone

form

powder

form

powder

form

powder

form

powder

assay

≥95%

assay

≥92%

assay

≥99%

assay

≥98%

technique(s)

inhibition assay: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

chloroform: methanol (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

solubility

chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to light yellow


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pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Domande

  1. What kind of impurities this product consists? According assays it is ≥95% cortisone. What compounds are included in remaining 5%?

    1 risposta
    1. The impurities that may be present in this product have not been identified. These impurites may include water and salts reminaining following the purification process.

      Utile?

Recensioni

Nessuna valutazione

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