C2436
Cytochrome c from Saccharomyces cerevisiae
≥85% based on Mol. Wt. 12,588 basis
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About This Item
Prodotti consigliati
Origine biologica
Saccharomyces cerevisiae
Livello qualitativo
Saggio
≥85% based on Mol. Wt. 12,588 basis
Stato
powder
PM
12,588 Da
tecniche
cell based assay: suitable
Solubilità
water: 10 mg/mL, clear, red to red-brown (dark red)
N° accesso UniProt
applicazioni
cell analysis
Temperatura di conservazione
−20°C
Informazioni sul gene
Saccharomyces cerevisiae ... CYC1(853507)
Descrizione generale
Cytochrome c (Cytc) comprises 104 amino acids and is a nuclear-encoded mitochondrial protein. This peripheral membrane protein is in spherical shape and has a molecular weight of 12,000 Da.
Applicazioni
Cytochrome c from Saccharomyces cerevisiae has been used in oocyte injection to induce caspase-3 activation and p38 MAPK (mitogen-activated protein kinase). It has also been used to analyze the aerobic reactions of nitric oxide.
Azioni biochim/fisiol
Cytochrome c (Cytc) participates in mitochondrial electron transport and intrinsic type II apoptosis. It plays a key role in aerobic energy production. This multi-functional enzyme serves as a single electron carrier. Cytc helps in the formation of the apoptosome.
The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen. Tracking cellular localization of cytochrome c in S. cerervisiae demonstrates that mitochondria are strongly involved in programmed cell death, a process very similar to apoptosis in higher organisms.
Qualità
Care has been taken to maintain the native form of the protein. It has not been artificially oxidized or reduced during purification. Contains variable amounts of reduced cytochrome c.
Nota sulla preparazione
Prepared without using TCA.
Altre note
View more information on cytochrome c and electron transport at www.sigma-aldrich.com/enzymeexplorer.
Applicazioni
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
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Membrane Proteins
The Membranes of Cells, 219-268 (2016)
Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite
SHARPE MA and Cooper CE
The Biochemical Journal, 332(1), 9-19 (1998)
The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: from respiration to apoptosis
Huttemann M, et al.
Mitochondrion, 11(3), 369-369 (2011)
Chromatograms
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