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A8346

Sigma-Aldrich

ProteoMass™ ACTH Fragment 18-39 MALDI-MS Standard

vial of 10 nmol, monoisotopic mol wt 2,464.1989 Da

Sinonimo/i:

Adrenocorticotropic hormone fragment 18-39

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5 X 1 VIAL
1.050,00 €

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About This Item

Numero CAS:
53917-42-3
Numero MDL:
MFCD00076159
Codice UNSPSC:
41116107
ID PubChem:
24891334
NACRES:
NA.24

1.050,00 €

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PM

monoisotopic mol wt 2,464.1989 Da

Livello qualitativo

100

Confezionamento

vial of 10 nmol

Stringa SMILE

CC(C)CC(NC(=O)C1CCCN1C(=O)C(Cc2ccccc2)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCC(O)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C3CCCN3C(=O)C(Cc4ccc(O)cc4)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(NC(=O)C5CCCN5C(=O)C(N)CCCNC(N)=N)C(C)C)C(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(Cc6ccccc6)C(O)=O

InChI

1S/C112H165N27O36/c1-56(2)48-72(100(163)125-70(37-41-86(148)149)97(160)133-77(111(174)175)51-63-24-14-11-15-25-63)129-103(166)79-28-20-46-138(79)109(172)75(49-62-22-12-10-13-23-62)131-93(156)61(9)121-95(158)68(35-39-84(144)145)123-92(155)60(8)122-102(165)78(55-140)134-98(161)71(38-42-87(150)151)126-101(164)74(53-88(152)153)128-96(159)69(36-40-85(146)147)124-91(154)59(7)120-83(143)54-119-94(157)73(52-82(115)142)130-104(167)80-29-21-47-139(80)110(173)76(50-64-31-33-65(141)34-32-64)132-107(170)89(57(3)4)135-99(162)67(27-16-17-43-113)127-106(169)90(58(5)6)136-105(168)81-30-19-45-137(81)108(171)66(114)26-18-44-118-112(116)117/h10-15,22-25,31-34,56-61,66-81,89-90,140-141H,16-21,26-30,35-55,113-114H2,1-9H3,(H2,115,142)(H,119,157)(H,120,143)(H,121,158)(H,122,165)(H,123,155)(H,124,154)(H,125,163)(H,126,164)(H,127,169)(H,128,159)(H,129,166)(H,130,167)(H,131,156)(H,132,170)(H,133,160)(H,134,161)(H,135,162)(H,136,168)(H,144,145)(H,146,147)(H,148,149)(H,150,151)(H,152,153)(H,174,175)(H4,116,117,118)
ZYDMZKPAPSZILB-UHFFFAOYSA-N

Amino Acid Sequence

Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe

Descrizione generale

The single peptide or protein standard is used to calibrate and test matrix assisted laser desorption ionization (MALDI) mass spectrometers. Adrenocorticotropic hormone (ACTH) is synthesized from its precursor pro-opiomelanocortin (POMC).[1] It is released from anterior pituitary gland in response to corticotropin-releasing hormone (CRH) from hypothalamus.[2]

Applicazioni

Peptide calibration standard for MALDI-MS instruments; 1 vial contains 10 nmols.
ProteoMass™ ACTH fragment 18-39 MALDI-MS standard has been used as a peptide calibration standard for matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry (MS) instruments. [3][4]

Azioni biochim/fisiol

Adrenocorticotropic hormone (ACTH) stimulates the synthesis and release of glucocorticoids and androgens through cAMP-dependent by a G-protein coupled receptor in adrenal gland.[1] Overproduction of ACTH leads to marked skin pigmentation.[1]

Stoccaggio e stabilità

Each standard is stored at room temperature and is shipped at ambient temperature. Standard stock solutions can be frozen in aliquots, but should not be subjected to more than 3 freeze-thaw cycles. Standard solutions are recommended for use for no longer than one month after reconstitution.

Note legali

ProteoMass is a trademark of Sigma-Aldrich Co. LLC

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLCP9239
0000255768
SLCH1511
SLCG6611
SLCC7474

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Endocrinology (2001)
Salivary peptidome profiling for diagnosis of severe early childhood caries.
Sun X, et al.
Journal of Translational Medicine, 14(1), 240-240 (2016)
Patient Education: A Practical Approach (2001)
Jessica L Costa et al.
General and comparative endocrinology, 136(1), 12-16 (2004-02-26)
alpha-Melanocyte stimulating hormone (MSH) and adrenocorticotropin (ACTH)1-24, the minimal ACTH sequence required for full activity, differ only by the 10 C-terminal amino acids of ACTH1-24. Interestingly, these ten C-terminal residues have been highly conserved throughout vertebrate evolution. To understand the
D Vieau et al.
The Journal of clinical endocrinology and metabolism, 79(5), 1503-1506 (1994-11-01)
POMC processing is frequently altered in ACTH-secreting nonpituitary tumors in which intermediate lobe-like peptides such as corticotropin-like intermediate lobe peptide (CLIP) are occasionally generated. In rodent pituitaries, the exclusive presence of prohormone convertase PC2 in the melanotrophs of the intermediate
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Articoli

Ultra-Pure MALDI Matrices

One of the most important aspects of our ultra-pure MALDI matrix substances is their ability to dissolve rapidly and completely; a brief vortex mixing is typically sufficient.

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