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I3377

Supelco

Isoniazide

analytical standard, ≥99% (TLC)

Sinonimo/i:

4-Pyridinecarboxylic acid hydrazide, INH, Idrazide isonicotinica, idrazide dell’acido isonicotinico

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About This Item

Formula empirica (notazione di Hill):
C6H7N3O
Numero CAS:
54-85-3
Peso molecolare:
137.14
Beilstein:
119374
Numero CE:
200-214-6
Numero MDL:
MFCD00006426
Codice UNSPSC:
41116107
ID PubChem:
329815370
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Saggio

≥99% (TLC)

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

171-173 °C (lit.)

Fluorescenza

λex 360 nm; λem 450 nm (thiol adduct)

Spettro attività antibiotica

mycobacteria

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

NNC(=O)c1ccncc1

InChI

1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
QRXWMOHMRWLFEY-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Chemical structure: pyridine
Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Antibiotico per il trattamento del Mycobacterium tuberculosis, inibisce la biosintesi dell'acido micolico. Metabolizzato dalla N-acetiltransferasi epatica (NAT) e dal citocromo P450 2E1 (CYP2E1) a formare epatotossine. Induce selettivamente l'espressione del CYP2E1. Inibisce reversibilmente le attività di CYP2C19 e CYP3A4 e inattiva meccanicisticamente CYP1A2, CYP2A6, CYP2C19 e CYP3A4 a concentrazioni clinicamente rilevanti.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315

Classi di pericolo

Acute Tox. 4 Oral - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificati d'analisi (COA)

Lot/Batch Number
0000376808
MKCW1792
0000376808
0000241662
MKCT7593

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Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study
Han DC, et al.
Clinical Orthopaedics and Related Research, 471(7), 2400-2406 (2013)
Ram Shankar Upadhayaya et al.
European journal of medicinal chemistry, 45(5), 1854-1867 (2010-02-09)
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at
Samantha Ellis et al.
Molecular pharmacology, 85(2), 269-278 (2013-11-19)
The rise in drug-resistant strains of Mycobacterium tuberculosis is a major threat to human health and highlights the need for new therapeutic strategies. In this study, we have assessed whether high-affinity iron chelators of the pyridoxal isonicotinoyl hydrazone (PIH) class
Standardized treatment of active tuberculosis in patients with previous treatment and/or with mono-resistance to isoniazid: a systematic review and meta-analysis.
Dick Menzies et al.
PLoS medicine, 6(9), e1000150-e1000150 (2010-01-28)
Molebogeng X Rangaka et al.
Lancet (London, England), 384(9944), 682-690 (2014-05-20)
Antiretroviral therapy reduces the risk of tuberculosis, but tuberculosis is more common in people with HIV than in people without HIV. We aimed to assess the effect of isoniazid preventive therapy on the risk of tuberculosis in people infected with
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