555553
Rho Kinase Inhibitor III, Rockout
The Rho Kinase Inhibitor III, Rockout, also referenced under CAS 7272-84-6, controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Sinonimo/i:
Rho Kinase Inhibitor III, Rockout, 3-(4-Pyridyl)-1H-indole
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10 MG
139,00 €
139,00 €
Spedizione prevista il18 aprile 2025Dettagli
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Cambia visualizzazione
10 MG
139,00 €
About This Item
Formula empirica (notazione di Hill):
C13H10N2
Numero CAS:
Peso molecolare:
194.23
Numero MDL:
Codice UNSPSC:
12352200
NACRES:
NA.54
139,00 €
Spedizione prevista il18 aprile 2025Dettagli
Prodotti consigliati
Livello qualitativo
Saggio
≥98% (HPLC)
Stato
solid
Produttore/marchio commerciale
Calbiochem®
Condizioni di stoccaggio
OK to freeze
protect from light
Colore
yellow
Solubilità
DMSO: 25 mg/mL
methanol: soluble
Condizioni di spedizione
ambient
Temperatura di conservazione
2-8°C
Stringa SMILE
[nH]1c2c(c(c1)c3ccncc3)cccc2
InChI
1S/C13H10N2/c1-2-4-13-11(3-1)12(9-15-13)10-5-7-14-8-6-10/h1-9,15H
LLJRXVHJOJRCSM-UHFFFAOYSA-N
Descrizione generale
A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 µM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
A cell-permeable, selective, reversible, and ATP-competitive inhibitor of Rho kinase activity (IC50 = 25 µM). Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 ~12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
Azioni biochim/fisiol
Cell permeable: yes
Primary Target
ROCK
ROCK
Product competes with ATP.
Reversible: yes
Target IC50: 25 µM against ROCK
Confezionamento
Packaged under inert gas
Attenzione
Toxicity: Standard Handling (A)
Ricostituzione
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Altre note
Yarrow, J.C., et al. 2005. Chem. Biol.12, 385.
Note legali
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
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