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481990

Sigma-Aldrich

Nigericin, Sodium Salt, Streptomyces hygroscopicus

Disrupts the membrane potential and stimulates ATPase activity in mitochondria.

Sinonimo/i:

Nigericin, Sodium Salt, Streptomyces hygroscopicus, Antibiotic K178

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About This Item

Formula empirica (notazione di Hill):
C40H67O11 · Na
Numero CAS:
28643-80-3
Peso molecolare:
746.94
Numero MDL:
MFCD00036825
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (TLC)

Forma fisica

lyophilized

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze

Solubilità

chloroform: soluble
ethanol: soluble
ethyl acetate: soluble

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

InChI

1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
MOYOTUKECQMGHE-KKCUGXASSA-M

Descrizione generale

A monocarboxylate that catalyzes the electroneutral exchange of an alkali metal for H+ (antiport). Transports monovalent cations across membranes with the following specificities: K+>Rb+>Cs+>>Na+. An antibiotic that kills bacteria by facilitating the diffusion of ions across membranes. Disrupts the membrane potential and stimulates mitochondrial ATPase activity.
Disrupts the membrane potential and stimulates ATPase activity in mitochondria. Transports monovalent cations across membranes with the following specificity: K+>Rb+>Cs+>>Na+.

Azioni biochim/fisiol

Cell permeable: no
Primary Target
Disrupts the membrane potential and stimulates ATPase activity in mitochondria.
Product does not compete with ATP.
Reversible: no

Attenzione

Toxicity: Toxic (F)

Ricostituzione

Following reconstitution, aliquot and freeze. Stock solutions are stable for 1 month at -20°C.

Altre note

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Moriyama, Y., et al. 1994. J. Biochem.115, 213.
Eytan, G.D., et al. 1990. J. Biol. Chem.265, 12949.
Alonso, M.A., and Carrasco, L. 1981. FEBS Lett.127, 112.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H319

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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