Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at [email protected] or 1800-325-5832.
LO4200
LOPAC®1280 - Small Scale
International Version
Sinonimo/i:
Library of Pharmacologically Active Compounds - small scale
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6.970,00 €
About This Item
6.970,00 €
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Descrizione generale
Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
Applicazioni
Library of pharmacologically active compounds LOPAC®1280 - small scale has been used to screen for the suppressors of niclosamide- and nigericin-induced interleukin (IL-1β) release.[1]
Caratteristiche e vantaggi
Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:
- Apoptosis
- G Proteins & Cyclic Nucleotides
- Gene Regulation & Expression
- Ion Channels
- Lipid Signaling
- Multi-Drug Resistance
- Neurotransmission
- Phosphorylation
SDFile provided to construct a database containing:
- Structure
- Primary Name
- Secondary Name
- Pharmacological Activity
- Product Number
- Rack Position
Altre note
For sale outside of the U.S. only. U.S. customers should refer to Product Code LO4100.
Note legali
LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany
Avvertenze
Danger
Indicazioni di pericolo
Classi di pericolo
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Punto d’infiammabilità (°F)
188.6 °F
Punto d’infiammabilità (°C)
87 °C
Elenchi normativi
Forniamo informazioni su eventuali restrizioni prevalentemente per i prodotti chimici. Per altre tipologie di prodotto siamo in grado di fornire soltanto informazioni limitate. Nessuna segnalazione significa che nessuno dei componenti è citato in un elenco. È dovere dell’utilizzatore assicurarsi che il prodotto venga impiegato in maniera sicura e a norme di legge.
EU REACH Annex XVII (Restriction List)
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High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston JM, Denning G, Moot R, et al.
Gene Therapy, doi:10-doi:10 (2014)
Laura M Alcântara et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-04)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Anzar Asad et al.
Basic & clinical pharmacology & toxicology, 133(4), 364-377 (2023-07-03)
Adhesion G protein-coupled receptors (GPCRs) are an underrepresented class of GPCRs in drug discovery. We previously developed an in vivo drug screening pipeline to identify compounds with agonist activity for Adgrg6 (Gpr126), an adhesion GPCR required for myelination of the
Xiao-Quan Liu et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(8), 523-537 (2020-05-18)
Although several nucleo(s)tide analogs are available for treatment of HBV infection, long-term treatment with these drugs can lead to the emergence of drug-resistant viruses. Recent HIV-1 studies suggest that combination therapies using nucleo(s)tide reverse transcriptase inhibitors (NRTIs) and non-nucleo(s)tide reverse
Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
Tran UT and Kitami T
Communications biology, 2(1), 2-2 (2019)
Articoli
Explore compound library screening options with our Pharmacologically Active Compounds portfolio.
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Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?
1 risposta-
Utile?
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What is the difference between the LOPAC1280 Products LO4200 and LO1280?
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The compound per well in LO4200 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280.
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Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?
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The information is available in the datasheet of a similar product LO1280.
Utile?
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Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?
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There is no CAS number list available.
Utile?
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What is the Department of Transportation shipping information for this product?
1 risposta-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Utile?
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What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?
1 risposta-
The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.
Utile?
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What is the difference between the LOPAC1280 Products LO4100 and LO4200?
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These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.
Utile?
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?
1 risposta-
Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.
Utile?
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Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 US approved?
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About 30% of the collection is made up of drugs approved for use in the US.
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Filtri attivi
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