850155P

18:1 PI(4,5)P2

Avanti Research^™ - A Croda Brand

• Sinonimo/i: 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[phosphoinositol-4,5-bisphosphate] (ammonium salt); PIP2[4′,5′](18:1(9Z)/18:1(9Z))
• Formula empirica (notazione di Hill): C₄₅H₉₄N₃O₁₉P₃
• Numero CAS: 799268-56-7
• Peso molecolare: 1074.16
• Numero MDL: MFCD22416812
• Codice UNSPSC: 51191904
• NACRES: NA.25

Proprietà

• Descrizione: 1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt)
• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 100 μg (with stopper and crimp cap (850155P-100ug)); pkg of 1 × 500 μg (with stopper and crimp cap (850155P-500ug))
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Tipo di lipide: phospholipids; cardiolipins
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

Descrizione

Descrizione generale

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Phosphatidylinositol is a structural phospholipid.[1] Phosphatidylinositol phosphate (PIP) is located in the plasma membrane.[2]

Applicazioni

18:1 PI(4,5)P2 is suitable to use as a supplement in native macrophage membranes to generate phospholipid enriched membrane liposome.s[3] It has also been used:

• in the preparation of anionic phospholipid liposomes[4]
• as a component in supported membrane tube (SMrT) templates[5]
• in liposome preparation[6]

Azioni biochim/fisiol

Phosphatidylinositol bisphosphate (PIP2) can effectively stimulate the ATPase.[2]

Confezionamento

2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3