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56485

Sigma-Aldrich

N-idrossisolfosuccinimide

≥98% (HPLC), for peptide synthesis

Sinonimo/i:

Acido idrossi-2,5-diossopirrolidina-3-solfonico, Solfo-NHS

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250 MG
104,00 €
1 G
315,00 €
5 G
1.250,00 €

104,00 €

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Cambia visualizzazione
250 MG
104,00 €
1 G
315,00 €
5 G
1.250,00 €

About This Item

Formula empirica (notazione di Hill):
C4H4NNaO6S
Numero CAS:
106627-54-7
Peso molecolare:
217.13
Beilstein:
6359129
Numero MDL:
MFCD00043100
Codice UNSPSC:
12352005
ID PubChem:
57651582
NACRES:
NA.22

104,00 €

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Nome del prodotto

N-idrossisolfosuccinimide, ≥98% (HPLC)

Livello qualitativo

200

Saggio

≥98% (HPLC)

Stato

powder

Composizione

carbon, 21.57-22.68 (anhydrous)
nitrogen, 6.28-6.61 (anhydrous)

Impiego in reazioni chimiche

reaction type: Addition Reactions

Impurezze

≤4% water

applicazioni

peptide synthesis

Gruppo funzionale

imide
sulfonic acid

Stringa SMILE

[Na+].ON1C(=O)CC(C1=O)S([O-])(=O)=O

InChI

1S/C4H5NO6S.Na/c6-3-1-2(12(9,10)11)4(7)5(3)8;/h2,8H,1H2,(H,9,10,11);/q;+1/p-1
RPENMORRBUTCPR-UHFFFAOYSA-M

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Categorie correlate

Applicazioni

Il sale sodico di N-idrossisolfosuccinimide è un analogo solfonato solubile in acqua dell′N-idrossisuccinimide. Può subire una reazione di accoppiamento con acidi carbossilici in presenza di carbodiimmidi come 1-etil-3-(3-dimetilaminopropil)carbodiimmide(EDC) per formare esteri attivi idrofili della N-idrossisolfosuccinimide. Questi esteri sono utili negli esperimenti sul cross-linking delle proteine[1][2]

Confezionamento

Flacone di vetro senza fondo. Il contenuto è all′interno di un cono fuso inserito.

Altre note

Sulfo-NHS è usato per la preparazione di esteri attivi idrofili, per esempio per gli agenti cross-linking.[3][4]

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM3588
BCCL3044
BCCJ9858
WXBF1499V
WXBF0098V

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N-hydroxysulfosuccinimide active esters: bis (N-hydroxysulfosuccinimide) esters of two dicarboxylic acids are hydrophilic, membrane-impermeant, protein cross-linkers.
Staros JV
Biochemistry, 21(17), 3950-3955 (1982)
Xiao-Yan Xu et al.
Journal of materials chemistry. B, 7(32), 4963-4972 (2019-08-15)
The construction of antibacterial and antitumor coatings could offer effective routes to improve the therapeutic effects of non-vascular stents for unresectable obstructions caused by malignant tumours. Herein, polyelectrolyte multilayers have been explored as bactericidal coatings with controlled antitumor drug release.
R Maydelid Trujillo-Nolasco et al.
Materials science & engineering. C, Materials for biological applications, 103, 109766-109766 (2019-07-28)
Radiosynovectomy is a technique used to decrease inflammation of the synovial tissue by intraarticular injection of a β-emitting radionuclide, such as 177Lu, which is suitable for radiotherapy due to its decay characteristics. Drug-encapsulating nanoparticles based on poly lactic‑co‑glycolic acid (PLGA)
P S Anjaneyulu et al.
International journal of peptide and protein research, 30(1), 117-124 (1987-07-01)
N-Hydroxysulfosuccinimide esters are reactive functional groups employed in a variety of protein modification reagents, especially cross-linking reagents. For these compounds, hydrolysis is the most important reaction competing for reaction of the esters with nucleophilic groups in proteins. We have employed
Karen S Cheung Tung Shing et al.
Scientific reports, 8(1), 12457-12457 (2018-08-22)
A direct interaction between the erythropoietin (EPOR) and the beta-common (βc) receptors to form an Innate Repair Receptor (IRR) is controversial. On one hand, studies have shown a functional link between EPOR and βc receptor in tissue protection while others
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Domande

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  3. What are the storage conditions for product 56485? There are no recommended conditions. Is it Room temp?

    1 risposta

    1. As mentioned in the Material Safery Data Sheet, section 7, it is recommended to store under inert gas such as argon or nitrogen. Please see the link below to review the SDS:
      https://www.sigmaaldrich.com/sds/aldrich/56485

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