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Merck

GRIN1

glutamate receptor, ionotropic, N-methyl D-aspartate 1

Sinonimi:
GluN1, MRD8, NMDA1, NMDAR1, NR1
Specie:
ID UniProtKB:
ID gene:
  • Human(2902) Summary: The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Mouse(14810) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • Rat(24408) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • naked mole-rat(101720185) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • Horse(100059861) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • chicken(404296) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • sheep(443281) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • cow(100336579) glutamate receptor, ionotropic, N-methyl D-aspartate 1
  • domestic guinea pig(100301989) glutamate receptor, ionotropic, NMDA1 (zeta 1)
  • dog(494007) glutamate receptor, ionotropic, N-methyl D-aspartate 1

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numero di prodotto
Descrizione
Specie
D-Serine, ≥98% (TLC),
Specie
human
Spermine tetrahydrochloride, powder or crystals,
Specie
human
Taurina, ≥99%,
Specie
human, rat
D-Cycloserine, synthetic,
Specie
human
Dextromethorphan hydrobromide monohydrate, ≥99% (TLC),
Specie
human

Small Molecule - Allosteric Modulator

Numero di prodotto
Descrizione
Specie
Ketamine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
Specie
human
(±)-Ketamine hydrochloride, solid,
Specie
human
S-(+)-Ketamine hydrochloride, ,
Specie
human
Ketamine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Acamprosate calcium, ≥98% (HPLC), powder,
Specie
human

Small Molecule - Antagonist

Numero di prodotto
Descrizione
Specie
MDL 105,519, ≥98% (HPLC), solid,
Specie
rat, human
CP-101,606, ≥98% (HPLC),
Specie
human
Dextrorphan tartrate, powder,
Specie
human
Ifenprodil (+)-tartrate salt, ,
Specie
human
Arcaine sulfate salt, ,
Specie
human

Antibodies

Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-NMDA Receptor 1/GRIN1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse
Applicazione
ELISA
immunofluorescence
Monoclonal Anti-Glun1-Nr1 antibody produced in mouse, clone S308-48, purified immunoglobulin,
Reattività con
human, mouse, rat
Applicazione
immunocytochemistry
immunohistochemistry

western blot
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-NMDAR1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot
Anti-GRIN1 (Ab-896) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
western blot

Small Molecule - Blocker

Numero di prodotto
Descrizione
Specie
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Specie
human
Agmatine sulfate salt, ≥97%, powder,
Specie
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Specie
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human

Small Molecule - Inhibitor

Numero di prodotto
Descrizione
Specie
Taurina, ≥99%,
Specie
human, rat
Pentamidine isethionate salt, powder,
Specie
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Specie
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Specie
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Specie
human

esiRNA

Numero di prodotto
Descrizione
Specie
MISSION® esiRNA, targeting human GRIN1,
Specie
human
MISSION® esiRNA, targeting mouse Grin1,
Specie
mouse