A0384

Arcaine sulfate salt

• Sinonimo/i: 1,4-Diguanidinobutane sulfate salt
• Formula empirica (notazione di Hill): C₆H₁₆N₆ · H₂O₄S
• Numero CAS: 14923-17-2
• Peso molecolare: 270.31
• Numero MDL: MFCD00050545
• Codice UNSPSC: 12352200
• ID PubChem: 24277954
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Saggio: ≥98% (TLC)
• Stato: powder
• Punto di fusione: >280 °C
• Solubilità: 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Stringa SMILE: OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
• InChI: 1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4); RWTGFMPOODRXIM-UHFFFAOYSA-N
• Informazioni sul gene: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

Descrizione

Applicazioni

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

• to evaluate its effects on the acquisition of electrical kindling of the amygdala[1]
• to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage[2]
• to study its effects on cell-free translation of synthetic polynucleotide[3]

Azioni biochim/fisiol

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine,[3] is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor.[4] Arcaine, an agmatine analog,[2] along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.[1]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)