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Merck

ACHE

acetylcholinesterase

Sinonimi:
ACEE, ARACHE, N-ACHE, YT
Specie:
ID UniProtKB:
ID gene:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

N° Catalogo
Descrizione
Specie
Pyridine-2-aldoxime methochloride, ,
Specie
human
(NE)-N-[(1-methylpyridin-1-ium-2-yl)methylidene]hydroxylamine;chloride, United States Pharmacopeia (USP) Reference Standard,
Specie
human

Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
Acetylthiocholine chloride, ≥99% (TLC), powder,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-Acetylcholinesterase (AChE) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
cat, human, mouse, rabbit, rat
Applicazione
ELISA
flow cytometry

immunofluorescence

western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
Reattività con
bovine, canine, chicken, guinea pig, human, monkey
Applicazione
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, rat
Applicazione
western blot
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
Donepezil hydrochloride, ≥98% (HPLC),
Specie
human
Scopoletin, ≥99%,
Specie
human
Pyridostigmine bromide, ,
Specie
human
Neostigmine bromide, ≥98% (HPLC and titration), powder,
Specie
human
Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC),
Specie
human

Kits

N° Catalogo
Descrizione
Specie
Acetylcholinesterase Activity Assay Kit, sufficient for 100 colorimetric tests,
Specie
mouse, human

Proteins

N° Catalogo
Descrizione
Specie
Acetylcholinesterase human, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
Specie
human
Acetylcholinesterase from human erythrocytes, buffered aqueous solution, ≥500 units/mg protein (BCA),
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human ACHE,
Specie
human