P9797

Pyridostigmine bromide

• Sinonimo/i: 3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
• Formula empirica (notazione di Hill): C₉H₁₃BrN₂O₂
• Numero CAS: 101-26-8
• Peso molecolare: 261.12
• Numero CE: 202-929-9
• Numero MDL: MFCD00079283
• Codice UNSPSC: 12352200
• ID PubChem: 24277865
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: solid
• Solubilità: water: 100 mg/mL, clear to very slightly hazy, colorless
• Ideatore: Valeant
• Stringa SMILE: [Br-].CN(C)C(=O)Oc1ccc[n+](C)c1
• InChI: 1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1; VNYBTNPBYXSMOO-UHFFFAOYSA-M
• Informazioni sul gene: human ... ACHE(43)

Descrizione

Applicazioni

Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice,[1] in florimetric assay for acetylcholine secretion[2] and for measuring acetylcholine release from mice atrial tissue.[3]

Azioni biochim/fisiol

Acetylcholinesterase inhibitor.

Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare.[4] Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract.[5] Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.[6]

Caratteristiche e vantaggi

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300 + H310 + H330,H317
• Consigli di prudenza: P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Classi di pericolo: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges