Y0002369

Saxagliptin monohydrate

CRS, European Pharmacopoeia (EP) Reference Standard

• Szinonimák: Saxagliptin hydrate, (S)-3-Hydroxyadamantylglycine-L-cis-4,5-methanoprolinenitrile hydrate, BMS 477118, BMS 477118-11, BMS-477118, BMS-477118-11, BMS477118, BMS477118-11
• Tapasztalati képlet (Hill-képlet): C₁₈H₂₅N₃O₂ · H₂O
• CAS-szám: 945667-22-1
• Molekulatömeg: 333.43
• UNSPSC kód: 41116107
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: saxagliptin
• gyártó/kereskedő neve: EDQM
• alkalmazás(ok): pharmaceutical
• tárolási hőmérséklet: 2-8°C
• SMILES string: OC12CC([C@@H](C(N3[C@@H](C[C@]4([C@@]3(C4)[H])[H])C#N)=O)N)(CC(C5)C2)CC5C1.O
• InChI: 1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2/t10?,11?,12-,13+,14+,15-,17?,18?;/m1./s1
• Nemzetközi kémiai azonosító kulcs: AFNTWHMDBNQQPX-NHKADLRUSA-N

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Saxagliptin monohydrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Saxagliptin (BMS-477118) is an orally active, highly potent and long-acting dipeptidyl peptidase IV inhibitor (human DPP-IV Ki = 0.9 nM; plasma DDP-IV inhibition = 87% 0.5-4h post 4 μmol/kg po. in normal rats) with therapeutic efficacy against type 2 diabetes in vivo (plasma glucose clearance = 28/43/61% post 0.3/1.0/3.0 μmol/kg po. in Zucker fa/fa rats).

Kiszerelés

Unit quantity: 130mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H317,H334,H361fd,H372
• Óvintézkedésre vonatkozó mondatok: P202 - P260 - P264 - P280 - P302 + P352 - P308 + P313
• Veszélyességi osztályok: Repr. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT RE 1
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable