12020AST
Astec® CHIROBIOTIC® T Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 2.1 mm, HPLC Column
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
41115700
eCl@ss:
32110501
NACRES:
SB.52
Javasolt termékek
product name
Astec® CHIROBIOTIC® T Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 2.1 mm
material
stainless steel column
Minőségi szint
Ügynökség
suitable for USP L63
leírás
HPLC column
termékcsalád
Astec®
kiszerelés
pkg of 1 ea
gyártó/kereskedő neve
Astec®
parameter
0-45 °C temperature
241 bar pressure (3500 psi)
technika/technikák
HPLC: suitable
LC/MS: suitable
H × belső átmérő
25 cm × 2.1 mm
matrix
High-purity silica gel particle platform
fully porous particle
mátrix aktív csoport
teicoplanin glycopeptide phase
részecskeméret
5 μm
pórusméret
100 Å
operating pH range
3.8-6.8
elválasztástechnika
chiral
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Általános leírás
CHIROBIOTIC® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity.
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
- Bonded phase: Teicoplanin
- Operating pH range: 3.8 - 6.8
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® T) or 200 Å (CHIROBIOTIC® T2)
CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature
Jogi információk
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
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D Abd el-Hady et al.
Journal of pharmaceutical and biomedical analysis, 37(5), 919-925 (2005-05-03)
A simple, sensitive and selective high performance liquid chromatographic method with UV detection for the chiral separation of racemic methotrexate (rac-Mtx) and enantiomeric purity of L-methotrexate in pharmaceutical formulations was developed and validated. The chiral separation was optimized studying both
Syntheses of racemic and non-racemic silicon- and germanium-containing a-amino acids of the formula type H2NCH(CH2ElR3)COOH (El=Si, Ge; R=organyl) and incorporation of d-H2NCH(CH2SiMe3)COOH and d-H2NCH(CH2GeMe3)COOH into biologically active decapeptides: a study on C/Si/Ge bioisosterism
Merget, Markus, et al.
Journal of Organometallic Chemistry, 628 (2), 183-194 (2001)
Berit P Jensen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 865(1-2), 48-54 (2008-03-07)
A stereoselective liquid chromatography-tandem mass spectrometry assay was developed and validated for quantification of S- and R-metoprolol at concentrations of 0.5-50 microg/L in human plasma. Metoprolol was extracted from plasma by liquid-liquid extraction with ethyl acetate (82% recovery). Chromatographic separation
Yuan-Qing Xia et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 788(2), 317-329 (2003-04-23)
An automated online sample extraction method for rat plasma was developed and validated for the quantification of (R)- and (S)-propranolol following the intravenous administration of either the racemate or the individual enantiomers at 5 mg/kg. A dual-column extraction system coupled
Effects of a strongly adsorbed additive on process performance in chiral preparative chromatography.
P Forssén et al.
Journal of chromatography. A, 1212(1-2), 89-97 (2008-10-31)
The shapes of elution profiles are often significantly influenced by the presence of strongly adsorbed additives in the mobile phase. This aspect needs to be considered in quantitative optimization of preparative chromatography. The theoretical study carried out here is based
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