SML0035

Tiagabine hydrochloride

≥98% (HPLC)

• Szinonimák: (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride
• Tapasztalati képlet (Hill-képlet): C₂₀H₂₅NO₂S₂ · HCl
• CAS-szám: 145821-59-6
• Molekulatömeg: 412.01
• MDL-szám: MFCD07369025
• UNSPSC kód: 12352200
• PubChem Substance ID: 329825105
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• optikai aktivitás: [α]/D -9 to -12°, c = 1 in H₂O
• szín: white to beige
• oldhatóság: H₂O: 10 mg/mL, clear
• kezdeményező: Cephalon
• tárolási hőmérséklet: 2-8°C
• SMILES string: Cl.Cc1ccsc1C(=CCCN2CCC[C@H](C2)C(O)=O)c3sccc3C
• InChI: 1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
• Nemzetközi kémiai azonosító kulcs: YUKARLAABCGMCN-PKLMIRHRSA-N
• Géninformáció: human ... SLC6A1(6529)

Leírás

Alkalmazás

Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells. It has also been used to study its anti-aging effects on the sensory neurons of C. elegans.

Biokémiai/fiziológiai hatások

Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.

Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders.

Tulajdonságok és előnyök

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Cephalon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable