SMB00311

Shogaol

≥90% (HPLC)

• Szinonimák: [6]-Shogaol, (6)-Shogaol, 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one
• Tapasztalati képlet (Hill-képlet): C₁₇H₂₄O₃
• CAS-szám: 555-66-8
• Molekulatömeg: 276.37
• Beilstein: 2056098
• MDL-szám: MFCD01736094
• UNSPSC kód: 12352205
• PubChem Substance ID: 329824943
• NACRES: NA.25

Tulajdonságok

• Minőségi szint: 200
• Teszt: ≥90% (HPLC)
• Forma: liquid
• alkalmazás(ok): metabolomics; vitamins, nutraceuticals, and natural products
• tárolási hőmérséklet: 2-8°C
• SMILES string: CCCCC\C=C\C(=O)CCc1ccc(O)c(OC)c1
• InChI: 1S/C17H24O3/c1-3-4-5-6-7-8-15(18)11-9-14-10-12-16(19)17(13-14)20-2/h7-8,10,12-13,19H,3-6,9,11H2,1-2H3/b8-7+
• Nemzetközi kémiai azonosító kulcs: OQWKEEOHDMUXEO-BQYQJAHWSA-N

Leírás

Általános leírás

Shogaol or 6-shogaol, the pungent metabolite of dried ginger, is one of the main bioactive compounds extracted from the natural dietary rhizome, Zingiber officinale Roscoe (ginger). It is the dehydrated successor of 6-gingerol with an α,β-unsaturated ketone skeleton.

Alkalmazás

Shogaol has been used to determine its safe dose to evaluate potential toxicity in higher concentrations in mice models. It has also been used to investigate its antioxidant effects on the modulation of TRPC5 (ITRPC5) and TRPA1 (ITRPA1) currents.

Biokémiai/fiziológiai hatások

Shogaols exhibits higher potency, efficacy, and biological activities than gingerols. It is an excellent antioxidant agent, that protects human primary epidermal melanocytes against oxidative stress by activating nuclear factor E2-related factor (Nrf2)-antioxidant response. Shogaol also displays antimicrobial, antifungal, and anti-biofilm activities against Candida albicans, and Candida auris. It exerts anti-inflammatory properties and protects against abdomen irradiation (ABI)-induced intestinal side effects. 6-shogaol also inhibits lipopolysaccharide (LPS)-induced inflammation via peroxisome proliferator-activated receptor gamma (PPAR-γ) activation.

Biztonsági adatok

• Piktogramok: GHS07
• Figyelmeztetés: Warning
• Figyelmeztető mondatok: H302
• Veszélyességi osztályok: Acute Tox. 4 Oral
• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable