SAB5700189

Anti-P21 antibody produced in rabbit

• Szinonimák: CAP20, CDKN1, CDKN1A, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
• UNSPSC kód: 12352203
• NACRES: NA.43
• klón: polyclonal
• application: WB
• faj reaktivitás: rat, mouse, human
• technika/technikák: western blot: 1:20-1:100

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: 18
• faj reaktivitás: rat, mouse, human
• koncentráció: 3.73 mg/ml
• technika/technikák: western blot: 1:20-1:100
• UniProt elérési szám: P38936
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... CDKN1A(1026)

Leírás

Általános leírás

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

Immunogén

Recombinant fusion protein containing a sequence corresponding to amino acids 1-164 of human P21 (NP_001207707.1).

Fizikai forma

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Tárolás és stabilitás

Store at -20℃. Avoid freeze / thaw cycles.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable