SAB5700132

Anti-CHCHD2 antibody produced in rabbit

• Szinonimák: C7orf17, CHCHD2, MNRR1, NS2TP, PARK22
• UNSPSC kód: 12352203
• NACRES: NA.43
• klón: polyclonal
• application: IF; IHC; WB
• faj reaktivitás: human, rat, mouse
• technika/technikák: immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: 15
• faj reaktivitás: human, rat, mouse
• koncentráció: 1.02 mg/ml
• technika/technikák: immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt elérési szám: Q9Y6H1
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... CHCHD2(51142)

Leírás

Általános leírás

The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.

Immunogén

Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).

Fizikai forma

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Tárolás és stabilitás

Store at -20℃. Avoid freeze / thaw cycles.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable