SAB4301658

Anti-CSPG4 Antibody

rabbit polyclonal

• Szinonimák: HMW-MAA, MCSP, MCSPG, MSK16, NG2
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• product name: Anti-CSPG4, affinity isolated antibody
• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• form: buffered aqueous glycerol solution
• faj reaktivitás: human, mouse, rat
• technika/technikák: immunohistochemistry: 1:20-1:100; western blot: 1:500-1:2000
• elérési szám: NP_001888
• UniProt elérési szám: Q6UVK1
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... CSPG4(1464)

Leírás

Általános leírás

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

Biokémiai/fiziológiai hatások

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

Tulajdonságok és előnyök

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Fizikai forma

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable