SAB4200704

Anti-EpCAM antibody, Mouse monoclonal

clone Ber-EP4, purified from hybridoma cell culture

• Szinonimák: Anti-CD326 antigen, Anti-EGP, Anti-Epithelial cell surface antigen, Anti-Epithelial glycoprotein, Anti-KS 1/4 antigen, Anti-KSA, Anti-Major gastrointestinal tumor-associated protein GA733-2, Anti-Tumor-associated calcium signal transducer 1
• UNSPSC kód: 12352203
• NACRES: NA.41
• klón: Ber-EP4, monoclonal
• application: IF; IHC; IP
• faj reaktivitás: human
• technika/technikák: immunofluorescence: 1-2 μg/mL using human breast adenocarcinoma MCF-7 cell line.; immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.; immunoprecipitation (IP): suitable
• citations: 8

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 200
• antitest forma: purified immunoglobulin
• antitest terméktípus: primary antibodies
• klón: Ber-EP4, monoclonal
• Forma: buffered aqueous solution
• faj reaktivitás: human
• koncentráció: ~1 mg/mL
• technika/technikák: immunofluorescence: 1-2 μg/mL using human breast adenocarcinoma MCF-7 cell line.; immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon carcinoma sections.; immunoprecipitation (IP): suitable
• izotípus: IgG1
• UniProt elérési szám: P16422
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... EPCAM(4072)

Leírás

Általános leírás

The epithelial cell adhesion molecule (EpCAM) is mapped to human chromosome 2p21 and has nine exons. EpCAM is a 40 kDa transmembrane glycoprotein present on cell surface. It has an intracellular domain called the EpICD, comprising of 26-amino acids. The extracellular domain (EpEX) has an epidermal growth factor (EGF) and a thyroglobulin repeat-like domain.

Immunogén

human breast carcinoma cell line MCF-7

Biokémiai/fiziológiai hatások

The epithelial cell adhesion molecule (EpCAM) is highly expressed in carcinomas. It regulates cell signalling, proliferation, migration and adhesion. Proteolytic cleavage of EpICD domain is crucial for tumor progression. EpCAM is highly expressed in breast cancer and is considered as a potential target for gene therapy. Deletions in the 3′ region of the EpCAM gene is associated with colorectal cancer based lynch syndrome. Single nucleotide polymorphism in EpCAM gene is associated with infant diarrheal disorder, congenital tufting enteropathy(CTE).

Fizikai forma

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable