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MAK136

Sigma-Aldrich

Monoamine Oxidase Activity Assay Kit

sufficient for 100 fluorometric tests

Szinonimák:

MAO Assay Kit

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
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About This Item

UNSPSC kód:
12161503
NACRES:
NA.84

használat

sufficient for 100 fluorometric tests

észlelési módszer

fluorometric

vonatkozó betegség(ek)

neurological disorders

tárolási hőmérséklet

−20°C

Géninformáció

human ... MAOA(4128) , MAOB(4129)
mouse ... MAOA(17161) , MAOB(109731)
rat ... MAOA(29253) , MAOB(25750)

Általános leírás

Monoamine oxidases (MAO, EC 1.4.3.4) are a family of mitochondrial enzymes that catalyze the oxidative deamination of monoamines. In mammals, MAO consists of two isoenzymes, MAO-A and MAO-B. MAO dysfunction is thought to be responsible for a number of neurological disorders. Unusually high or low levels of MAO in the body have been associated with depression, schizophrenia, substance abuse, attention deficit disorder, migraines, and irregular sexual maturation. MAO inhibitors are one of the major classes of drug prescribed for the treatment of depression.

Alkalmazás

Monoamine Oxidase Activity Assay Kit has been used to estimate MAO-A (monoamine oxidase A), MAO-B (monoamine oxidase B) and ALDH (aldehyde dehydrogenase) activities.

Tulajdonságok és előnyök

Compatible with high-throughput handling systems.

Alkalmasság

Suitable for the determination of MAO activity in biological samples and for the screening of MAO inhibitors. Can determine either MAO-A, MAO-B or both MAO-A and MAO-B activity.

Elv

The Monoamine Oxidase Assay Kit provides a convenient fluorimetric means to measure MAO enzyme activity in biological samples. In the assay, MAO reacts with p-tyramine, a substrate for both MAO-A and MAO-B, resulting in the formation of H2O2, which is determined by a fluorimetric method (λex = 530/λem = 585 nm). The assay is simple, sensitive, stable, and high-throughput adaptable. Unit definition: one unit of MAO catalyzes the formation of 1 μmole of H2O2 per minute under the assay conditions.

Tárolási osztály kódja

10 - Combustible liquids

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Juho-Matti Renko et al.
Molecular neurobiology, 55(8), 6755-6768 (2018-01-20)
Neurotrophic factors (NTFs) hold potential as disease-modifying therapies for neurodegenerative disorders like Parkinson's disease. Glial cell line-derived neurotrophic factor (GDNF), cerebral dopamine neurotrophic factor (CDNF), and mesencephalic astrocyte-derived neurotrophic factor (MANF) have shown neuroprotective and restorative effects on nigral dopaminergic
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats.
Renko J M, et al.
Molecular Neurobiology, 1-14 (2018)
Umut Salgin-Goksen et al.
Journal of medicinal chemistry, 64(4), 1989-2009 (2021-02-04)
Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N'-(1,3-disubstitutedphenylallylidene)-2-(5-substituted-2-benzoxazolinone-3-yl)acetohydrazide skeleton were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of
Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.
Oria V O, et al.
Translational Oncology, 11(6), 1307-1322 (2018)
Lovedeep Singh et al.
Metabolic brain disease, 36(1), 111-121 (2020-09-02)
Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies. Thus, there is a need to develop an efficacious alternate treatment regimen for pain-depression dyad. Skimmetin and osthole are molecules
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