Összes fotó(5)
Fontos dokumentumok
D6694
Anti-DSCR1 (C-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Szinonimák:
Anti-ADAP78, Anti-Calcipressin 1, Anti-DSC1, Anti-Down Syndrome Candidate Region 1, Anti-MCIP1, Anti-Myocyte-enriched calcineurin-interacting protein 1, Anti-RCAN1, Anti-RCN1, Anti-Regulator of calcineurin 1
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(5)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.44
konjugátum:
unconjugated
application:
WB
klón:
polyclonal
faj reaktivitás:
mouse, rat, human
citations:
39
technika/technikák:
western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
konjugátum
unconjugated
antitest forma
affinity isolated antibody
antitest terméktípus
primary antibodies
klón
polyclonal
Forma
buffered aqueous solution
molekulatömeg
antigen ~26 kDa
faj reaktivitás
mouse, rat, human
koncentráció
~1.5 mg/mL
technika/technikák
western blot: 2-4 μg/mL using HEK-293T cells expressing human DSCR1
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... RCAN1(1827)
mouse ... Dscr1(54720)
rat ... Dscr1(266766)
Általános leírás
DSCR1 (Down Syndrome Candidate Region 1 is encoded by a gene mapped to human chromosome 21q22.1. DSCR1 belongs to a family of conserved proteins named regulators of calcineurin (RCAN), that in humans include RCAN, encoded by the DSCR1L1-2 genes. DSCR1 is highly expressed in the central nervous system (CNS) during early embryonic development, in heart, and in skeletal muscle.
Egyediség
Anti-DSCR1 (C-terminal) antibody is specific for DSCR1 in rats, mice and humans. The immunizing peptide specifically inhibits the staining of DSCR1 by immunoblotting.
Immunogén
Synthetic peptide corresponding to a sequence at C-terminal of human DSCR1, conjugated to KLH. This sequence is identical in human DSCR1 isoforms a and b, and rat and mouse DSCR1.
Alkalmazás
Anti-DSCR1 (C-terminal) antibody is suitable for use in western blot (2-4 μg/mL using HEK-293T cells expressing human DSCR1) and in immunoblotting (approx. 26 kDa).
Anti-DSCR1 (C-terminal) antibody produced in rabbit has been used in proximity ligation assay (PLA) and immunoblotting.
Biokémiai/fiziológiai hatások
Down Syndrome Candidate Region 1 (DSCR1) is involved in cellular adaptation to oxidative stress, and interacts with calcineurin to inhibit its phosphatase activity, thereby regulating the calcineurin- Nuclear factor of activated T-cells (NFAT) signaling pathway and affecting central nervous system (CNS) development and angiogenesis. Chronic overexpression of DSCR1 has been implicated in additional pathological conditions including Alzheimer′s disease and cardiac hypertrophy, possibly through inhibition of calcineurin activity. DSCR1 is induced by vascular endothelial growth factor (VEGF) in activated endothelial cells and regulates the expression of inflammatory marker genes such as interleukin-8 (IL-8), tissue factor, E-selectin and cyclooxygenase (Cox-2).
Down Syndrome Candidate Region 1 or DSCR1 is a candidate gene involved in the pathogenesis of Down′s Syndrome (DS). DSCR1 is usually expressed in cardiac, skeletal and brain tissues, whereas its overexpression in fetal brain tissues is associated with DS. DSCR1 inhibits calcineurin-mediated mRNA synthesis.
Fizikai forma
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2)
Strippoli P, et al.
Genomics, 64(3), 252-263 (2000)
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells
Hesser BA, et al.
Blood, 104(1), 149-158 (2004)
Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease
Harris CD, et al.
Cellular and Molecular Life Sciences, 62(21), 2477-2486 (2005)
Xiaoding Wang et al.
Cell death and differentiation, 25(12), 2181-2194 (2018-04-19)
Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) stimulates the unfolded protein response (UPR), which communicates between the ER and
Csaba Galambos et al.
PloS one, 11(8), e0159005-e0159005 (2016-08-04)
Infants with Down syndrome (DS) or Trisomy 21, are at high risk for developing pulmonary arterial hypertension (PAH), but mechanisms that increase susceptibility are poorly understood. Laboratory studies have shown that early disruption of angiogenesis during development impairs vascular and
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