A6354

Anti-Adiponectin antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Szinonimák: Adiponectin Antibody, Anti-Adiponectin antibody produced in rabbit, Anti-Adipocyte Complement-Related Protein of 30 kDa
• MDL-szám: MFCD03454695
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• form: buffered aqueous solution
• faj reaktivitás: mouse, human
• koncentráció: ~1 mg/mL
• technika/technikák: western blot (chemiluminescent): 0.5-1 μg/mL using using human plasma or placenta, or an extract of differentiated 3T3-L1 mouse cells.
• UniProt elérési szám: Q15848
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... ADIPOQ(9370) ; mouse ... Adipoq(11450)

Leírás

Általános leírás

Adiponectin is secreted from adipose tissue for the regulation of glucose and fatty acid break down.

Anti-Adiponectin is produced in rabbit using a synthetic peptide corresponding to amino acid residues of human adiponectin. Adiponectin, also designated as adipocyte complement-related protein of 30 kDa (Acrp30), AdipoQ, apM1, Gelatin-binding protein 28 kDa (GBP28) is an adipocyte-specific protein that circulates in the blood stream, where it accounts for approximately 0.01% of all plasma proteins. Adiponectin belongs to the complement factor C1q family that belongs to the soluble defense collagen superfamily. Adiponectin (ADIPOQ) protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain.

It is recommended to dilute the antibody in phosphate buffered saline containing 0.5% non-fat dry milk for background staining reduction.

Egyediség

Rabbit Anti-Adiponectin antibody recognizes human and mouse adiponectin.

Immunogen

synthetic peptide corresponding to amino acid residues 225-244 of human adiponectin with N-terminal added cysteine, conjugated to KLH.

Alkalmazás

Anti-Adiponectin antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Rabbit Anti-Adiponectin antibody has been used for immunohistochemical and western blot applications.

Biokémiai/fiziológiai hatások

Adipose tissue has important roles in energy storage, glucose homeostasis and fat metabolism.(10) Increased adiponectin levels are associated with type I diabetes mellitus, anorexia nervosa, weight reduction, and chronic renal failure. Adiponectin (ADIPOQ) affects lipid catabolism by increasing fatty acid oxidation in muscle, modulates glucose uptake, alters liver gluconeogenesis and enhances insulin-sensitivity in both muscle and liver. ADIPOQ has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.

Fizikai forma

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable