402OA-05A

Human Chondrocytes - Osteoarthritis: HC-OA, adult

• Szinonimák: HC-OA cells
• UNSPSC kód: 41106514
• NACRES: NA.81

Tulajdonságok

• biológiai forrás: human articular cartilage (osteoarthritic)
• Minőségi szint: 100
• kiszerelés: pkg of 500,000 cells
• gyártó/kereskedő neve: Cell Applications, Inc
• növekedési mód: Adherent
• kariotípus: 2n = 46
• morfológia: chondrocyte
• technika/technikák: cell culture | mammalian: suitable
• vonatkozó betegség(ek): arthritis
• kiszállítva: dry ice
• tárolási hőmérséklet: −196°C

Leírás

Általános leírás

Lot specific orders are not able to be placed through the web. Contact your local sales rep for more details.

HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.

Characterization: Positive for aggrecan after differentiation.

HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).

Sejtvonal eredete

Cartilage

Alkalmazás

model for studying chondrocyte biology in an osteoarthritis joint

Komponensek

Basal Medium containing 10% FBS & 10% DMSO

Elkészítési megjegyzés

• 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
• Can be cultured at least 10 doublings

Szubkultúra rutin

Please refer to the HC-OA Culture Protocol.

Jogi nyilatkozat

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable