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Merck
Összes fotó(2)

Fontos dokumentumok

402OA-05A

Sigma-Aldrich

Human Chondrocytes - Osteoarthritis: HC-OA, adult

Szinonimák:

HC-OA cells

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

UNSPSC kód:
41106514
NACRES:
NA.81

biológiai forrás

human articular cartilage (osteoarthritic)

Minőségi szint

kiszerelés

pkg of 500,000 cells

gyártó/kereskedő neve

Cell Applications, Inc

növekedési mód

Adherent

kariotípus

2n = 46

morfológia

chondrocyte

technika/technikák

cell culture | mammalian: suitable

vonatkozó betegség(ek)

arthritis

kiszállítva

dry ice

tárolási hőmérséklet

−196°C

Általános leírás

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HC-OA Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis (OA). Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-OA provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the OA joint.

Characterization: Positive for aggrecan after differentiation.

HC-OA have been used to demonstrate that THF-alpha activates transcription of ADAMTS-4, a metalloproteinase implicated in cartilage degradation in OA, via p38-MAPK-dependent mechanism (Xue, 2013).

Sejtvonal eredete

Cartilage

Alkalmazás

model for studying chondrocyte biology in an osteoarthritis joint

Komponensek

Basal Medium containing 10% FBS & 10% DMSO

Elkészítési megjegyzés

  • 1st passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

Szubkultúra rutin

Please refer to the HC-OA Culture Protocol.

Jogi nyilatkozat

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

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Dokumentumtár megtekintése

Quanzhi Liang et al.
BMC geriatrics, 21(1), 57-57 (2021-01-16)
Osteopontin plays critical roles in osteoarthritis (OA) by regulating the functions of osteoclasts. It is known that osteopontin can induce the expression of lncRNA HOX transcript antisense RNA (HOTAIR), indicating the involvement of HOTAIR in OA. This study was carried
Hongfei Zhang et al.
Clinical rheumatology, 39(11), 3473-3478 (2020-05-11)
LncRNA CTBP1-AS2 has been reported to be involved in type 2 diabetes and cardiomyocyte hypertrophy, while its roles in other human diseases are unknown. Our preliminary deep sequencing analysis showed altered expression of CTBP1-AS2 in osteoarthritis (OA). In addition, CTBP1-AS2
Xiangxiang Sun et al.
International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory cytokines are controlled by inflammasomes, especially NLRP1 (NLR Family Pyrin Domain Containing 1) and NLRP3.

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