294R-1
BOB.1 (SP92) Rabbit Monoclonal Antibody
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
Javasolt termékek
biológiai forrás
rabbit
Minőségi szint
100
500
konjugátum
unconjugated
antitest forma
culture supernatant
antitest terméktípus
primary antibodies
klón
SP92, monoclonal
leírás
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
faj reaktivitás
human
kiszerelés
vial of 0.1 mL concentrate (294R-14)
vial of 0.5 mL concentrate (294R-15)
bottle of 1.0 mL predilute (294R-17)
vial of 1.0 mL concentrate (294R-16)
bottle of 7.0 mL predilute (294R-18)
gyártó/kereskedő neve
Cell Marque™
technika/technikák
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
izotípus
IgG1
szabályozó
B-cell lymphoma, tonsil
kiszállítva
wet ice
tárolási hőmérséklet
2-8°C
vizualizáció
nuclear
Géninformáció
human ... POU2AF1(5450)
Általános leírás
Expression of BOB.1/OBF.1 is restricted largely to mature B-cells. Germinal center B-cells normally demonstrate strong staining for BOB.1, as do mantle-zone B-cells, and plasma cells. Analyses of BOB.1/OBF.1 expression in a variety of established B-cell lines representing different stages of B-cell development has suggested a constitutive, B-cell-specific expression pattern. Because they are germinal center derived, L&H cells in nodular lymphocyte predominant Hodgkin lymphoma are consistenty immunoreactive for BOB.1. Conversely, the Hodgkin/Reed- Sternberg cells in classical Hodgkin lymphoma either do not express both (80%) or express only one (20%) of the two proteins. In B-cell lymphomas, the highest expression levels for BOB.1/OBF.1 are reported in follicular center lymphomas, diffuse large B-cell lymphomas and Burkitt lymphomas.B-CLL, MALT-type, and mantle cell lymphomas score negative or display an heterogenous/weaker reactivity.10-11 Studies have suggested that anti-BOB. has a high predictive value in discriminating primary mediastinal B-cell lymphoma from classical Hodgkin disease.Approximately 50% of acute myeloid leukemias express BOB.1.
Kapcsolódás
BOB.1 Positive Control Slides, Product No. 294S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Fizikai forma
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Elkészítési megjegyzés
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Egyéb megjegyzések
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Jogi információk
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
Nem találja a megfelelő terméket?
Próbálja ki a Termékválasztó eszköz. eszközt
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
Már rendelkezik ezzel a termékkel?
Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Susanne Annette Steimle-Grauer et al.
Virchows Archiv : an international journal of pathology, 442(3), 284-293 (2003-03-21)
The World Health Organization (WHO) classification of Hodgkin lymphoma (HL) distinguishes two types: Classical Hodgkin lymphoma (CHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). Both groups have in common that they mostly derive from B cells with rare classical cases
A Greiner et al.
The American journal of pathology, 156(2), 501-507 (2000-02-10)
The BOB.1/OBF.1/OCAB.1 protein is a lymphocyte-specific transcriptional coactivator. It interacts with the Oct1 and Oct2 transcription factors and contributes to the transcriptional activity of octamer motifs. The analysis of established B cell lines had suggested that BOB.1/OBF.1 is constitutively expressed
Ana-Isabel Sáez et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 15(3), 211-220 (2002-03-21)
Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating B-cell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as BOB.1/OBF.1. Independent
H Stein et al.
Blood, 97(2), 496-501 (2001-01-12)
In contrast to the tumor cells (L&H cells) of lymphocyte predominant Hodgkin disease (LPHD), Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin disease (cHD) are unable to transcribe immunoglobulin, despite the presence of rearranged immunoglobulin genes. Although initial studies have
Juliette J Hoefnagel et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(9), 1270-1276 (2006-06-17)
Expression patterns of eight transcription factors involved in different stages of B-cell development were investigated in a large group of primary cutaneous B-cell lymphomas and compared with expression patterns during normal B-cell development. The following transcription factors were investigated: Pax-5
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
Lépjen kapcsolatba a szaktanácsadással