MABC532

Anti-PTHrP Antibody, clone 4C4.1

clone 4C4.1, from mouse

• Szinonimák: Parathyroid hormone-related protein, PTHrP, PTH-rP, Parathyroid hormone-like protein, PLP
• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 100
• antitest forma: purified immunoglobulin
• antitest terméktípus: primary antibodies
• klón: 4C4.1, monoclonal
• faj reaktivitás: human
• technika/technikák: western blot: suitable
• izotípus: IgG1κ
• NCBI elérési szám: NP_945316
• UniProt elérési szám: P12272
• kiszállítva: wet ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... PTHLH(5744)

Leírás

Általános leírás

Parathyroid hormone-related protein (UniProt P12272; also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid preproprotein with an N-terminal signal sequence (aa 1-24) and a propeptide sequence (aa 25-34), which are later removed to yield the mature protein. The mature protein is further cleaved to produce PTHrP[1-34] (aa 37-70), PTHrP[1-36] (aa 37-72), PTHrP[38-94] (aa 74-130), and PTHrP[107-139] (aa 143-175; also known as Osteostatin). PTHrP is produced in a wide variety of tissues, where it acts as a paracrine or autocrine factor to regulate cellular and organ growth, development, migration, differentiation, calcium transport, survival and apoptosis.

Immunogen

GST-tagged recombinant human PTHrP lacking signal and propeptide sequence.

Alkalmazás

Detect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.

Minőség

Evaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected PTHrP in 10 µg of MCF-7 cell lysate.

Cél megnevezése

~16/6 kDa observed. Uncharacterized band(s) may appear in some lysates.

Fizikai forma

Format: Purified

Egyéb megjegyzések

Concentration: Please refer to lot specific datasheet.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable