Ugrás a tartalomra
Merck
Összes fotó(1)

Fontos dokumentumok

MAB2627

Sigma-Aldrich

Anti-VCAM-1 (CD106) Antibody, clone 6C7.1

clone 6C7.1, from rat

Szinonimák:

vascular cell adhesion molecule 1, vascular cell adhesion protein 1, CD106 antigen

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biológiai forrás

rat

Minőségi szint

100

antitest forma

purified immunoglobulin

antitest terméktípus

primary antibodies

klón

6C7.1, monoclonal

faj reaktivitás

mouse

technika/technikák

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

izotípus

IgG1κ

NCBI elérési szám

NP_035823

UniProt elérési szám

P29533

kiszállítva

dry ice

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... L1CAM(3897) , VCAM1(7412)

Általános leírás

Vascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor.

Immunogen

Mouse endothelial cells

Alkalmazás

Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.
Immunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)

Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)

Minőség

Evaluated by Flow Cytometry in mouse bone marrow cells.

Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.

Cél megnevezése

81 kDa calculated

Fizikai forma

Format: Purified

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Nem találja a megfelelő terméket?  

Próbálja ki a Termékválasztó eszköz. eszközt

Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 2

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

David S Ojala et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 26(1), 304-319 (2017-10-11)
Directed evolution continues to expand the capabilities of complex biomolecules for a range of applications, such as adeno-associated virus vectors for gene therapy; however, advances in library design and selection strategies are key to develop variants that overcome barriers to
Gahee Min et al.
Journal of cellular and molecular medicine, 20(12), 2333-2340 (2016-07-16)
Drug repositioning is used to discover drug candidates to treat human diseases, through the application of drugs or compounds that are approved for the treatment of other diseases. This method can significantly reduce the time required and cost of discovering
Chao Ma et al.
Science advances, 6(44) (2020-11-01)
B cell acute lymphoblastic leukemia (B-ALL) blasts hijack the bone marrow (BM) microenvironment to form chemoprotective leukemic BM "niches," facilitating chemoresistance and, ultimately, disease relapse. However, the ability to dissect these evolving, heterogeneous interactions among distinct B-ALL subtypes and their
Peter Baluk et al.
Methods in molecular biology (Clifton, N.J.), 2441, 115-134 (2022-02-01)
Changes in blood vessels and lymphatics in health and disease are easier to understand and interpret when studied microscopically in three dimensions. The mouse trachea is a simple, yet powerful, and versatile model system in which to achieve this. We

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

Lépjen kapcsolatba a szaktanácsadással