5.30799

AGE Inhibitor, LR-90

• Szinonimák: AGE Inhibitor, LR-90, Advanced Glycation Endproducts Inhibitor
• Tapasztalati képlet (Hill-képlet): C₃₅H₃₄Cl₂N₄O₈
• CAS-szám: 245075-84-7
• Molekulatömeg: 709.57
• MDL-szám: MFCD00099039
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Teszt: ≥97% (HPLC)
• Minőségi szint: 100
• Forma: powder
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: off-white
• oldhatóság: DMSO: 100 mg/mL
• tárolási hőmérséklet: 2-8°C

Leírás

Általános leírás

A cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC₅₀ = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-κB.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

A cell-permeable methylene bisphenylureido derived compound that blocks the formation of advanced glycation endproduct (AGE) by scavenging dicarbonyl intermediates and by chelating transition metals that catalyze the production of AGE. Inhibits metal ion-catalyzed oxidation of ascorbate (IC₅₀ = 275 µM). Exhibits protective effects against diabetic nephropathy, retinopathy, and atherosclerosis and reduces arterial stiffness in diabetic animals (~50 mg/L drinking water) by reducing collagen accumulation and cross-linking. Although it does not affect glycemic condition and body weight in normal and diabetic animals, it reduces plasma triglycerides and glycated hemoglobin levels in diabetic rats and improves their cardiac output and stroke volume. Also shown to suppress S100b and TNFa-induced activation of NF-kB.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
=IF(SGM_MetricTransfer!C11=,,SGM_MetricTransfer!C11)

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Satheesan, S., et al. 2014. Br. J. Pharmacol.171, 3103.

Nagai, R., et al. 2012. Diabetes.61, 549.
Figarola, J.L., et al. 2008. Diabetologia.51, 882.
Figarola, J.L., et al. 2003. Diabetologia.46, 1140.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable