5.08839

BIBR1532

≥98% (HPLC), solid, telomerase inhibitor, Calbiochem^®

• Szinonimák: Telomerase Inhibitor X, BIBR1532, BIBR 1532, BIBR-1532
• Tapasztalati képlet (Hill-képlet): C₂₁H₁₇NO₃
• CAS-szám: 321674-73-1
• Molekulatömeg: 331.36
• MDL-szám: MFCD11112195
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Terméknév: Telomerase Inhibitor X, BIBR1532,
• Teszt: ≥98% (HPLC)
• Minőségi szint: 100
• Forma: solid
• hatékonyság: 93 nM IC₅₀
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: off-white
• oldhatóság: DMSO: 100 mg/mL
• tárolási hőmérséklet: 2-8°C
• SMILES string: N(c3c(cccc3)C(=O)O)C(=O)\C=C(/C)\c1cc2c(cc1)cccc2
• InChI: 1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
• Nemzetközi kémiai azonosító kulcs: PGFQXGLPJUCTOI-WYMLVPIESA-N

Leírás

Általános leírás

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

A cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC₅₀ = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
Teomerase

Reversible: yes

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Damm, K., et al. 2001. The. EMBO J.20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem.277,15566.

Nakashima, M., et al. 2013. J. Biol. Chem.288, 33171.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable