208722

Calpain Inhibitor III

The Calpain Inhibitor III, also referenced under CAS 88191-84-8, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Szinonimák: Calpain Inhibitor III, Carbobenzoxy-valinyl-phenylalaninal, MDL 28170
• Tapasztalati képlet (Hill-képlet): C₂₂H₂₆N₂O₄
• CAS-szám: 88191-84-8
• Molekulatömeg: 382.45
• MDL-szám: MFCD00798796
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• Forma: lyophilized solid
• hatékonyság: 8 nM IC₅₀
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• szín: white
• oldhatóság: DMSO: 20 mg/mL (Use only anhydrous DMSO.)
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C
• SMILES string: N([C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)C=O)C(=O)OCc1ccccc1
• InChI: 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1
• Nemzetközi kémiai azonosító kulcs: NGBKFLTYGSREKK-PMACEKPBSA-N

Leírás

Általános leírás

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

Biokémiai/fiziológiai hatások

Cell permeable: yes

Primary Target
calpain 1, calpain 2

Product does not compete with ATP.

Reversible: no

Figyelmeztetés

Toxicity: Standard Handling (A)

Szekvencia

Z-Val-Phe-CHO

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Egyéb megjegyzések

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable