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Merck

850371P

Avanti

22:0 PC

1,2-dibehenoyl-sn-glycero-3-phosphocholine, powder

Szinonimák:

1,2-didocosanoyl-sn-glycero-3-phosphocholine; PC(22:0/22:0)

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Tapasztalati képlet (Hill-képlet):
C52H104NO8P
CAS-szám:
Molekulatömeg:
902.36
MDL-szám:
UNSPSC kód:
51191904
NACRES:
NA.25

Teszt

>99% (TLC)

Forma

powder

kiszerelés

pkg of 1 × 1 g (850371P-1g)
pkg of 1 × 25 mg (850371P-25mg)
pkg of 1 × 500 mg (850371P-500mg)

gyártó/kereskedő neve

Avanti Research - A Croda Brand 850371P

lipidtípus

phospholipids
cardiolipins

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCCCCCC)=O)=O

InChI

1S/C52H104NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-42-44-51(54)58-48-50(49-60-62(56,57)59-47-46-53(3,4)5)61-52(55)45-43-41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h50H,6-49H2,1-5H3

Nemzetközi kémiai azonosító kulcs

HRTBOPUWPUXROO-UHFFFAOYSA-N

Általános leírás

Phosphatidylcholines (PCs) are amphipathic molecules, that are mainly located on the outer leaflets of the biological membrane bilayer. Approximately 40–50% of the total cellular phospholipids consists of phosphatidylcholine.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Alkalmazás

22:0 PC may be used:
  • to study its effects on non-amyloidogenic processing of amyloid precursor protein (APP)/α-secretase activity
  • to prepare a lipid monolayer to study whether ligand is specifically targeted to domains containing Cu(II)-iminodiacetate lipid (Cu-PSIDA)
  • as a lipid standard for the quantification of lipid species from lipid droplets by hydrophilic interaction liquid chromatography-high performance liquid chromatography (HILIC-HPLC)

Biokémiai/fiziológiai hatások

Phosphatidylcholines (PCs) can serve as lung surfactant.

Kiszerelés

20 mL Clear Glass Screw Cap Vial (850371P-1g)
20 mL Clear Glass Screw Cap Vial (850371P-500mg)
5 mL Amber Glass Screw Cap Vial (850371P-25mg)

Jogi információk

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

Lot/Batch Number

Sajnos jelenleg COA nem áll rendelkezésre ehhez a termékhez online.

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Dokumentumtár megtekintése

K Maloney et al.
Chemistry & biology, 3(3), 185-192 (1996-03-01)
Chemical information is sometimes transmitted across cell membranes by ligand-induced assembly of receptors. We have previously designed a series of lipids with metal-chelating headgroups that can serve as general receptors for proteins containing accessible histidines. Such lipids can also be
Elinor Thompson et al.
Healthcare technology letters, 6(5), 138-142 (2019-12-14)
Oxygen loaded microbubbles are being investigated as a means of reducing tumour hypoxia in order to improve response to cancer therapy. To optimise this approach, it is desirable to be able to measure changes in tissue oxygenation in real-time during
Estelle Beguin et al.
Journal of controlled release : official journal of the Controlled Release Society, 317, 23-33 (2019-11-17)
Recent pre-clinical studies have demonstrated the potential of combining chemotherapy and sonodynamic therapy for the treatment of pancreatic cancer. Oxygen-loaded magnetic microbubbles have been explored as a targeted delivery vehicle for this application. Despite preliminary positive results, a previous study
Pinunta Nittayacharn et al.
Frontiers in pharmacology, 11, 644-644 (2020-06-02)
Drug delivery to solid tumors using echogenic nanobubbles (NBs) and ultrasound (US) has recently gained significant interest. The approach combines attributes of nanomedicine and the enhanced permeation and retention (EPR) effect with the documented benefits of ultrasound to improve tumor
Bingbing Cheng et al.
Scientific reports, 9(1), 20020-20020 (2019-12-29)
Real-time acoustic feedback control based on harmonic emissions of stimulated microbubbles may be important for facilitating the clinical adoption of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening, both to ensure safe acoustic exposures, and to achieve repeatable and consistent opening.

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