Ugrás a tartalomra
Merck

938904

Sigma-Aldrich

TissueFab® Discrete GelMA

300 bloom, 50% degree of substitution

Szinonimák:

GeIMA, Gelatin Methacrylate, Gelatin methacrylamide

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Lineáris képlet:
(C32H48N9O11)n
CAS-szám:
MDL-szám:
UNSPSC kód:
12352202

Minőségi szint

leírás

Application: 3D bioprinting, tissue engineering

Forma

(powder or chunk(s) or fibers)

szín

, white to light brown

tárolási hőmérséklet

−20°C

Általános leírás

Gelatin methacryloyl, also known as gelatin methacrylate or GelMA, is a methacrylate-functionalized gelatin biomaterial. The gelatin amine groups are chemically modified with methacrylate groups, which when combined with light and a photoinitiator, can be be photopolymerized to form a hydrogel with a three-dimension network that closely mimices the native extracellular matrix (ECM). GelMA is often used as a scaffold for cell culture and tissue regeneration, as it provides a supportive environment for cell attachment, proliferation, and differentation. Its properties, such as mechanical strength, degradation rate, and gelation behavior, can be adjusted by modifying the degree of methacrylation and crosslinking density.

Many GelMAs currently available have a high degree of variation and inconsistency. To address this, the TissueFab(R) Discrete GelMAs have been developed to achieve a specific degree of methacrylation with low batch to batch variability.

Alkalmazás

  • Tissue engineering - including bone tissue, cartilage tissue, epidermal tissue, and cardiac tissue
  • Regenerative medicine - including injectable tissue constructs and endothelial cell morphogenesis
  • Drug and cell delivery - in the form of microspheres and hydrogels
  • Surface coatings - of medical devices and implants in order to improve biocompatibility and release therapuetic cargos

Tulajdonságok és előnyök

  • Specific degree of methacrylation - a narrow peak of methacrylation allows for better reproducibility, low batch to batch variability, for improved consistency of gel properties and cell behavior.
  • Biocompatibility - GelMA contains RGD sequences, found in collagen and other natural ECM proteins, which promote cell adhesion, proliferation, differentiation, and maturation of a variety of cell types.
  • Biodegradability - GelMA contains matrix metalloproteinase (MMP) degradable sites that can be recognized and enzymatically degraded by cells. This allows the encapsulated cells to degrade and remodel the GelMA matrix, and repopulate with their own cells and tissues, a major goal for tissue engineering and regenerative medicine.
  • Tunability - The TissueFab(R) Discrete GelMAs are available in a variety of degrees of substitution which ultimately impact the hydrogel stiffness and mechanical properties and can be used to recapitulate and accomodate different native tissues.
  • Bioprintability - The TissueFab(R) Discrete GelMAs are widely used in the field of 3D bioprinting due to their unique gelation properties and the ability to print via extrusion and other methods to create intricate cell-encapsulated 3D structures with high cell viability.

Jogi információk

TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Photocrosslinkable gelatin hydrogel for epidermal tissue engineering.
Zhao X, et al.
Advanced Helathcare Materials (2015)
Tissue engineering of retina through high resolution 3-dimensional inkjet bioprinting.
Masaeli, et al.
Biofabrication, 12, 25006-25006 (2020)
Facile one-step micropatterning using photodegradable methacrylated gelatin hydrogels for improved cardiomyocyte organization and alignment.
Tsang K, et al.
Advances in Functional Materials, 25(6), 977-986 (2015)
Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels
Bertassoni LE, Cardoso JC, Manoharan V, et al.
Biofabrication, 6(2), 024105-024105 (2014)
Cell-laden microengineered gelatin methacrylate hydrogels.
Nichol JW, Koshy ST, Bae H, et al.
Biomaterials, 31(21), 5536-5544 (2010)

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