920517

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid

• Szinonimák: Rigid linker for PROTAC^® development
• Tapasztalati képlet (Hill-képlet): C₁₅H₂₂N₄O₄
• CAS-szám: 1700483-37-9
• Molekulatömeg: 322.36
• MDL-szám: MFCD34602224
• UNSPSC kód: 12352106
• NACRES: NA.22

Tulajdonságok

• reakcióalkalmasság: reagent type: linker
• Minőségi szint: 100
• funkcionális csoport: Boc; carboxylic acid
• tárolási hőmérséklet: 2-8°C
• SMILES string: CC(C)(OC(N1CCCN(C2=CN=CC(C(O)=O)=N2)CC1)=O)C
• InChI: 1S/C15H22N4O4/c1-15(2,3)23-14(22)19-6-4-5-18(7-8-19)12-10-16-9-11(17-12)13(20)21/h9-10H,4-8H2,1-3H3,(H,20,21)

Leírás

Alkalmazás

6-(4-(tert-Butoxycarbonyl)-1,4-diazepan-1-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920525
920681

Egyéb megjegyzések

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable