910066

6-(2-(2-(Oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid

≥90%

• Szinonimák: 6-2-2-6 PROTAC^® linker, Alkyne-PEG₃-acid, Bifunctional linker
• Tapasztalati képlet (Hill-képlet): C₁₈H₃₂O₅
• Molekulatömeg: 328.44
• UNSPSC kód: 12352106
• Forma: liquid
• Teszt: ≥90%

Tulajdonságok

• Teszt: ≥90%
• Forma: liquid
• reakcióalkalmasság: reagent type: linker
• funkcionális csoport: alkyne; carboxylic acid
• tárolási hőmérséklet: 2-8°C
• SMILES string: OC(CCCCCOCCOCCOCCCCCCC#C)=O

Leírás

Alkalmazás

This heterobifunctional, PEGylated crosslinker 6-(2-(2-(oct-7-yn-1-yloxy)ethoxy)ethoxy)hexanoic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₃-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 6-2-2-6.

Egyéb megjegyzések

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

Jogi információk

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable